Last update 13 Dec 2025

TAK-637

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TAK 637, TAK637
Target
NK1R
Action
antagonists
Mechanism
NK1R antagonists(Neurokinin 1 receptor antagonists)
Therapeutic Areas
Nervous System DiseasesDigestive System DisordersUrogenital Diseases
Active Indication-
Inactive Indication
Depressive Disorder, MajorIrritable Bowel SyndromePollakisuria+ [2]
Originator Organization
Takeda Pharmaceutical Co., Ltd.Takeda Pharmaceutical Co., Ltd.
Active Organization-
Inactive Organization
Takeda Pharmaceutical Co., Ltd.Takeda Pharmaceutical Co., Ltd.
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC30H25F6N3O2
InChIKeyLDXQLWNPGRANTO-UHFFFAOYSA-N
CAS Registry217185-75-6

Related

100 Clinical Results associated with TAK-637
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100 Translational Medicine associated with TAK-637
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100 Patents (Medical) associated with TAK-637
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24
Literatures (Medical) associated with TAK-637
01 Jan 2015Bioorganic & medicinal chemistry
Retraction notice to “3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis” [Bioorg. Med. Chem. 19 (2011) 5175–5182]
01 Dec 2014Bioorganic & medicinal chemistry
Retraction notice to ‘Corrigendum to “3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis”’ [Bioorg. Med. Chem. 20 (2012) 5668–5668]
01 Sep 2012BIOORGANIC & MEDICINAL CHEMISTRY
RETRACTED: Corrigendum to “3-Benzhydryl-4-piperidones as novel neurokinin-1 receptor antagonists and their efficient synthesis” [Bioorg. Med. Chem. 19 (2011) 5175–5182]
100 Deals associated with TAK-637
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 2
United States
--
Depressive Disorder, MajorPhase 2-
Takeda Pharmaceutical Co., Ltd.Takeda Pharmaceutical Co., Ltd.
-
Irritable Bowel SyndromePhase 2
United States
--
Irritable Bowel SyndromePhase 2-
Takeda Pharmaceutical Co., Ltd.Takeda Pharmaceutical Co., Ltd.
-
PollakisuriaPhase 2
Europe
--
Urinary Bladder, OveractivePhase 2-
Takeda Pharmaceutical Co., Ltd.Takeda Pharmaceutical Co., Ltd.
-
Urinary IncontinencePhase 2
United States
--
Urinary IncontinencePhase 2
Europe
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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