Efficacy and safety of tosufloxacin tosilate hydrate for the treatment of community-acquired pneumonia in children - Efficacy and safety of TFLX fine granules for the treatment of CAP in children

Start Date08 Oct 2010

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100 Clinical Results associated with Tosufloxacin Tosilate Hydrate

100 Translational Medicine associated with Tosufloxacin Tosilate Hydrate

100 Patents (Medical) associated with Tosufloxacin Tosilate Hydrate

737

Literatures (Medical) associated with Tosufloxacin Tosilate Hydrate

01 May 2025·Marine Pollution Bulletin

Historical distribution and multi-dimensional environmental risk assessments of antibiotics in coastal sediments affected by land-based human activities

Article

Author: Cao, Feng ; Li, Feifei ; Su, Zhiguo ; Chen, Lyujun ; Yang, Wendy ; Zheng, Yuhan ; Wen, Donghui

Coastal sediment cores provide important records of land-based antibiotics' deposition. This study examined sediment cores from the Hangzhou Bay, East China Sea, dating back to 1980-2020 using 210Pbex. The 40-year analysis revealed a mismatch between sediment depth and age. Wastewater treatment facilities have significantly reduced antibiotics discharge into the sea. We identified 27 antibiotics, with enrofloxacin (ERFX) and nadifloxacin (NDFX) exhibiting the highest average concentrations of 84.9 and 83.4 ng/g, respectively. Quinolones (QNs) were prominent, displaying strong co-occurrence and similar distribution patterns shaped by comparable soil-water distribution coefficient (K_d). QNs correlated positively with total antibiotic concentration, serving as indicators. We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks.

21 Apr 2025·Journal of Drug Targeting

Artificial intelligence-based molecular property prediction of photosensitising effects of drugs

Article

Author: Ibbotson, Sally ; Hofmann, Amun G. ; Agibetov, Asan ; Weber, Benedikt

Drug-induced photosensitivity is a potential adverse event of many drugs and chemicals used across a wide range of specialties in clinical medicine. In the present study, we investigated the feasibility of predicting the photosensitising effects of drugs and chemical compounds via state-of-the-art artificial intelligence-based workflows. A dataset of 2200 drugs was used to train three distinct models (logistic regression, XGBoost and a deep learning model (Chemprop)) to predict photosensitising attributes. Labels were obtained from a list of previously published photosensitisers by string matching and manual validation. External evaluation of the different models was performed using the tox21 dataset. ROC-AUC ranged between 0.8939 (Chemprop) and 0.9525 (XGBoost) during training, while in the test partition it ranged between 0.7785 (Chemprop) and 0.7927 (XGBoost). Analysis of the top 200 compounds of each model resulted in 55 overlapping molecules in the external validation set. Prediction scores in fluoroquinolones within this subset corresponded well with culprit substructures such as fluorinated aryl halides suspected of mediating photosensitising effects. All three models appeared capable of predicting photosensitising effects of chemical compounds. However, compared to the simpler model, the complex models appeared to be more confident in their predictions as exhibited by their distribution of prediction scores.

01 Apr 2025·Internal Medicine

Renal Impairment Caused by Tosufloxacin Crystals in an Adult

Article

Author: Hayashi, Tomofumi

100 Deals associated with Tosufloxacin Tosilate Hydrate

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KEGG	Wiki	ATC	Drug Bank
-	Tosufloxacin Tosilate Hydrate	D07XA02 D07AA03 S02BA03 A07EA01 C05AA04 S03BA02 S01CB02 H02AB06 R01AD02 S01BA04	-

R&D Status

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Indication	Country/Location	Organization	Date
Blepharitis	Japan	Nitto Medic Co., Ltd.	23 Jan 2006
Corneal Ulcer	Japan	Nitto Medic Co., Ltd.	23 Jan 2006
Dacryocystitis	Japan	Nitto Medic Co., Ltd.	23 Jan 2006
Hordeolum	Japan	Nitto Medic Co., Ltd.	23 Jan 2006
Keratitis	Japan	Nitto Medic Co., Ltd.	23 Jan 2006

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ERS2012	Not Applicable	MR gene	152	Macrolides	sfzhxisdaa(hzcnowzzum) = The DNA copy numbers in the MR patients showed little decrease after macrolide administration, but rapid decrease after administration of minocycline or tosufloxacin ojorhmfgjs (rmnqymhqsj )	-	01 Sep 2012
				Minocycline
63459 (ARVO2007)	Not Applicable	-	-	Moxifloxacin Ophthalmic Solution	hyjqhrcwlv(jkdcakxybl) = rnkyldvyyo aokvyyjtjs (omrkgmznbs )	Positive	01 May 2007
				Levofloxacin Ophthalmic Solution	hyjqhrcwlv(jkdcakxybl) = nyzvbhhdrp aokvyyjtjs (omrkgmznbs )

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