Anti-EPCAM CAR-T cell therapy(Beijing Sinobioway Bioengineering Group Co Ltd)

SOUTH SAN FRANCISCO, Calif., Jan. 03, 2023 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical-stage T-cell reprogramming company dedicated to developing curative cell therapies for patients with solid tumors, announced today that members of its senior management team will present and participate in the 41st Annual J.P. Morgan Healthcare Conference on Tuesday, January 10 at 4:30 pm Pacific Time. At the conference, Lyell executives will highlight the company’s growing pipeline of product candidates targeting solid tumors and T-cell reprogramming technologies, including its: Lead CAR T cell and TIL product candidates, LYL797 and LYL845, which are in Phase 1 clinical development;Second-generation ROR1 targeting CAR T-cell product candidate, LYL119, that incorporates two new reprogramming technologiesNewest stackable genetic and epigenetic reprogramming technologies: NR4A3 gene knockout, that is being incorporated along with c-Jun overexpression to enhance the functional activity of CAR T cells; andStim-RTM, a programmable cell-signaling platform that optimizes signaling parameters during T-cell activation in order to generate more potent CAR T cells A live webcast of the presentation can be accessed through the Investors section of the Company's website at www.lyell.com. Following the live presentation, a replay of the webcast will be available on the Company's website for 30 days following the presentation date. About Lyell Immunopharma, Inc. Lyell is a clinical-stage T-cell reprogramming company advancing a pipeline of therapies designed to address what it believes are the primary barriers that limit consistent and long-lasting responses to adoptive T-cell therapy: T cell exhaustion and lack of durable stemness, which includes the ability to persist and self-renew to drive durable tumor cytotoxicity. Lyell is applying its proprietary ex vivo genetic and epigenetic reprogramming technologies to address these barriers in order to develop new medicines with improved and durable clinical outcomes. Lyell is based in South San Francisco, California with facilities in Seattle and Bothell, Washington. To learn more, please visit www.lyell.com. Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements expressed or implied in this press release include, but are not limited to, statements regarding: Lyell’s anticipated progress, business plans, business strategy, planned research and clinical trials and plans to present at the conference; the growing pipeline of product candidates and T-cell reprogramming technologies and the potential clinical benefits and therapeutic potential of such product candidates and technologies; the potential of Lyell’s reprogramming technologies to overcome primary barriers to successful adoptive cell therapy in solid tumors, including the ability for Lyell’s new genetic and epigenetic reprogramming technologies to enhance the functional activity of CAR T cells and to generate more potent CAR T cells, and Lyell’s plans for such reprogramming technologies; and other statements that are not historical fact. These statements are based on Lyell’s current plans, objectives, estimates, expectations and intentions, are not guarantees of future performance and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, but are not limited to, risks and uncertainties related to: the effects of the COVID-19 pandemic; geopolitical instability; macroeconomic conditions; Lyell’s ability to submit planned INDs or initiate or progress clinical trials on the anticipated timelines, if at all; Lyell’s lack of experience as a company in enrolling, conducting or completing clinical trials; Lyell’s ability to manufacture and supply its product candidates for its clinical trials; the preclinical profiles of Lyell’s product candidates not translating in clinical trials; the potential for results from clinical trials to differ from preclinical, early clinical, preliminary or expected results; significant adverse events, toxicities or other undesirable side effects associated with Lyell’s product candidates; the significant uncertainty associated with Lyell’s product candidates ever receiving any regulatory approvals; Lyell’s ability to obtain, maintain or protect intellectual property rights related to its product candidates; implementation of Lyell’s strategic plans for its business and product candidates; the sufficiency of Lyell’s capital resources and need for additional capital to achieve its goals; and other risks, including those described under the heading “Risk Factors” in Lyell’s most recently filed quarterly report on Form 10-Q and subsequent filings with the Securities and Exchange Commission. Forward-looking statements contained in this press release are made as of this date, and Lyell undertakes no duty to update such information except as required under applicable law. Contact: Ellen RoseSenior Vice President, Communications and Investor Relationserose@lyell.com

Tessa to prioritize allogeneic CAR-T cell therapy platform following strong safety and efficacy data presented during ASH 2022SINGAPORE, Jan. 03, 2023 (GLOBE NEWSWIRE) -- Tessa Therapeutics Ltd. (Tessa), a clinical-stage cell therapy company developing next-generation cancer treatments for hematological malignancies and solid tumors, announced today that the company will prioritize development of its allogeneic “off-the-shelf” CD30.CAR-modified Epstein-Barr virus-specific T-cell (EBVST) therapy platform, while seeking strategic options for the development of its TT11 autologous CAR-T platform with other companies. The decision to prioritize the allogeneic or “off-the-shelf-approach” over the autologous platform followed progress and new data with its TT11X clinical program, including strong safety and efficacy data presented in an oral podium presentation at the 64th Annual Meeting of the American Society of Hematology (ASH). The data demonstrated TT11X to be well-tolerated at all dosing levels, eliciting a 79% overall response rate and 43% complete response rate among 14 heavily pre-treated CD30-positve Hodgkin lymphoma patients. These developments are the first of what is expected to be a milestone-rich year ahead for Tessa as the company seeks to build the value of its pipeline to its fullest potential with available resources. “I believe that this strategic refocus on our allogeneic platform positions the company at the forefront of CAR-T innovation during 2023 and beyond,” stated Thomas Willemsen, President and CEO of Tessa Therapeutics. “This optimism is based on the compelling safety and efficacy data that continue to be generated by our TT11X program and the potential patient benefit in treating CD30-positive lymphomas, and potentially solid tumors where there is significant unmet medical need.” “Our scientific efforts are directed toward enhancing cell performance and durability of our allogeneic EBVST cells - a key challenge faced by current allogeneic approaches, and hence a key differentiating factor in our platform approach.” stated Ivan Horak, M.D., Chief Medical Officer and Chief Scientific Officer of Tessa Therapeutics. Tessa Corporate Update During 2022, Tessa enhanced its executive management team with the appointment of Thomas Willemsen as President and CEO and Wilson W. Cheung as CFO. The company also expanded its board with the addition of Amy Schulman and Darren Carroll from Polaris Partners, which led the company’s US$126M Series A round. Today, Tessa has announced that Steve Krognes will serve as the company’s new Chairman of the Board of Directors. Mr. Krognes, who was previously a director on Tessa’s Board, replaces Dr. Göran Ando as Chairman after nearly three years. “We are very pleased to welcome Steve Krognes to Chairman of the Board. Steve brings a deep background in business development and partnering and will work closely with management as we embark on this important period in the company’s evolution,” stated Mr. Willemsen. “We would like to extend our deepest gratitude to Dr. Ando for his leadership and contribution to the growth and development of Tessa. He has been instrumental in our company’s success and his influence will be felt at Tessa for years to come.” Tessa Therapeutics at “JPM Week 2023” The Tessa executive team will be in San Francisco during “JPM Week 2023” and available for one-on-one meetings with accredited investors, as well as biotech and pharmaceutical companies to discuss partnering opportunities and to execute its plan for the manufacturing facility divestiture. For those interested in scheduling meetings, please contact Jonathan Nugent (jnugent@tiberend.com) and Daniel Kontoh-Boateng (dboateng@tiberend.com). About Tessa Therapeutics Singapore-based Tessa Therapeutics is a clinical-stage biotechnology company developing next-generation cell therapies for the treatment of hematological cancers and solid tumors. Tessa’s CAR-T portfolio is highlighted by a proprietary allogeneic “off-the-shelf” cell therapy platform targeting a broad range of cancers in which Epstein Barr Virus Specific T Cells (EBVSTs) are augmented with CD30-CAR. A therapy using this platform, TT11X, is currently the subject of a Phase 1 clinical trial in CD30-positive lymphomas. Tessa’s pipeline also includes TT11, an autologous CD30-CAR-T therapy being investigated as a potential treatment for relapsed or refractory classical Hodgkin lymphoma as both a monotherapy (Phase 2) and combination therapy (Phase 1b). For more information on Tessa, visit www.tessacell.com. Cautionary Note on Forward Looking StatementsThis press release contains forward-looking statements (within the meaning of the Private Securities Litigation Reform Act of 1995, to the fullest extent applicable) including, without limitation, with respect to various regulatory filings or clinical study developments of the Company. You can identify these statements by the fact that they use words such as “anticipate,” “estimate”, “expect”, “project”, “intend”, “plan”, “believe”, “target”, “may”, “assume” or similar expressions. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those related to the Company’s financial results, the ability to raise capital, dependence on strategic partnerships and licensees, the applicability of patents and proprietary technology, the timing for completion of the clinical trials of its product candidates, whether and when, if at all, the Company’s product candidates will receive marketing approval, and competition from other biopharmaceutical companies. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made, and disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Company’s views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. The Company’s products are expressly for investigational use pursuant to a relevant investigational device exemption granted by the U.S. Food & Drug Administration, or equivalent competent body. Tessa Therapeutics Investor Contact Wilson W. Cheung Chief Financial Officer wcheung@tessacell.com Tessa Therapeutics Media Contact Tiberend Strategic Advisors, Inc. Bill Borden +1-732-910-1620 bborden@tiberend.com Dave Schemelia +1-609-468-9325 dschemelia@tiberend.com