As the treatments for liver disease and the availability of liver transplantation have progressed, the number of patients with end stage liver disease continues to increase. This has increased the need to risk-stratify patients with cirrhosis to better direct their treatments and provide an accurate prognosis for their outcomes. The traditional assessment of the liver patient has been limited to imaging, static measures of "liver function tests" and liver biopsy. This protocol is designed to increase the spectrum of tests in the evaluation of the patient with end stage liver disease.

Start Date01 Jul 2011

Sponsor / Collaborator

Baylor Research Institute

100 Clinical Results associated with Sodium Cholate Hydrate

100 Translational Medicine associated with Sodium Cholate Hydrate

100 Patents (Medical) associated with Sodium Cholate Hydrate

646

Literatures (Medical) associated with Sodium Cholate Hydrate

15 Apr 2025·ACS Nano

Precise Partitioning of Metallic Single-Wall Carbon Nanotubes and Enantiomers through Aqueous Two-Phase Extraction

Article

Author: Li, Han ; Fagan, Jeffrey A. ; Zheng, Ming

Separation of single-chirality single-wall carbon nanotubes (SWCNTs) and their enantiomers holds significant potential for materials science and various applications but challenges in scalability and precision persist. In this study, we introduce a systematic approach to identify separation conditions for metallic SWCNTs in aqueous two-phase extraction (ATPE), precisely identifying improved conditions for isolating multiple armchair and chiral (n,m) species. We quantify these conditions by determining partition coefficient change condition (PCCC) values for both binary and ternary surfactant combinations. This information enables optimization for efficient separation of high-purity armchair nanotubes such as (6,6), (7,7), (8,8) and (9,9), and for isolation of enantiomeric nonarmchair nanotubes, including challenging metallic species such as the (8,5), (7,4), (9,3), (10,4) and (10,7). Lastly, separated single (n,m) populations are reseparated in ATPE at precise steps in both binary and ternary surfactant mixtures to resolve their enantiomers, extracting information on the underlying mechanism of metallic SWCNT ATPE and highlighting the utility of sodium cholate for achieving single enantiomer level separations.

01 Apr 2025·Naunyn-Schmiedeberg's Archives of Pharmacology

Enhanced behavioral impact of optimized bupropion-encapsulated bilosomes over traditional niosomes treating depression

Article

Author: Vajagathali, Mohammed ; Kiran, Venkatakrishnan ; Bose, Debosreeta ; Girigoswami, Agnishwar ; Girigoswami, Koyeli ; Durgadevi, Pazhani ; Harini, Karthick ; Thirumalai, Anbazhagan

Bupropion (Bpn), an FDA-approved NDRI (norepinephrine-dopamine reuptake inhibitor), poses risks of seizures and liver failure due to its stimulant properties, necessitating the development of alternative formulations. This research aims to develop a Bpn nanoformulation within bilosomal vesicles to enhance therapeutic efficacy at lower doses, using three bile salts, span 20 surfactants, and cholesterol via thin-film hydration. Optimization of bilosomal stability is achieved by trialing various ingredient concentrations, identifying a surfactant-to-cholesterol-to-bile salt ratio of 1.5:1:0.17 µM, with sodium cholate (B.SC_F) yielding the most stable system. Bpn encapsulated in the optimized bilosomal vesicle (Bpn@B.SC _F) demonstrated high encapsulation efficiency of 78.142 ± 11.07% and drug-retaining capacity compared to the niosomal system. The in vitro and in vivo toxicity profile of the product is superior to the niosomal system and shows negligible toxicity with a viability rate of not less than 95%, with a sustained release profile in artificial cerebrospinal fluid (ACSF). In vivo, behavioral analysis on zebrafish revealed that Bpn@B.SC _F treatment more effectively improved depressive behavior compared to free Bpn and other treatments, evidenced by increased exploration rates and reduced irregular movements, as shown through statistical and trajectory data. Hence, it is concluded that the bilosomal structure, compared to the niosomal system, is a better carrier of drugs to achieve brain delivery and improve mood.

01 Mar 2025·Food Chemistry

Sodium cholate-coated Olea europaea polyphenol nanoliposomes: Preparation, stability, release, and bioactivity

Article

Author: Halabalaki, Maria ; Angelis, Apostolis ; Zhou, Hao ; Skaltsounis, Leandros A ; Antoniadi, Lemonia ; Qi, Zhiwen ; Chen, Hongxia ; Wang, Chengzhang ; Li, Wenjun

Ultra-flexible nanoliposomes (UNL) coated with sodium cholate were fabricated using the thin film hydration technique to encapsulate oleocanthal (OLEO), oleacein (OLEA), oleuropein (OLEU), and hydroxytyrosol (HT) for improving their stability and bioactivity. Their physicochemical properties were further validated through DLS, FTIR, XRD, TGA, and DSC analyses. Negative-staining TEM imaging revealed well-dispersed UNL with laminar vesicles inside. Additionally, their transdermal studies in vitro demonstrated that UNL enhanced the cumulative release of OLEO, OLEA, OLEU, and HT by 3.13, 2.76, 2.59, and 2.83 times, respectively. Furthermore, their release mechanisms were better approximated the Peppas-Sahlin model rather than the Korsmeyer-Peppas and Higuchi models, which governed by Fickian diffusion. Moreover, comparing to their compounds, UNL structure exhibited improved their antioxidant and cytotoxicity properties, highlighting their potential as effective delivery agents in humans. These results offer a novel approach for stabilizing biologically active polyphenols from Olea europaea, paving the way for enhanced human health applications.

100 Deals associated with Sodium Cholate Hydrate

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