As the treatments for liver disease and the availability of liver transplantation have progressed, the number of patients with end stage liver disease continues to increase. This has increased the need to risk-stratify patients with cirrhosis to better direct their treatments and provide an accurate prognosis for their outcomes. The traditional assessment of the liver patient has been limited to imaging, static measures of "liver function tests" and liver biopsy. This protocol is designed to increase the spectrum of tests in the evaluation of the patient with end stage liver disease.

Start Date01 Jul 2011

Sponsor / Collaborator

Baylor Research Institute

100 Clinical Results associated with Sodium Cholate Hydrate

100 Translational Medicine associated with Sodium Cholate Hydrate

100 Patents (Medical) associated with Sodium Cholate Hydrate

1,646

Literatures (Medical) associated with Sodium Cholate Hydrate

01 Dec 2024·Psychiatry Research: Neuroimaging

Neuroimaging-based drug discovery for amyloid clearance therapy in Alzheimer's disease using validated causation analysis

Article

Author: Roy, Prasun K ; Purohit, Pratik ; Bhattacharjee, Anindita ; Roy, Prasun K.

Aging-induced hepatic dysfunction can impair cholesterol metabolism, reducing the availability of cholic acid (CA, bile-acid) in brain. CA is reported to have neuroprotective characteristics in preclinical investigations of Alzheimer's disease (AD). Our aim is to probe the causal-connectivity between the players: amyloid, cholic acid and cerebral-blood-flow, and thereby explore therapeutic applicability in AD. From AD neuroimaging initiative biospecimen platform, we evaluated serum cholic-acid (182 healthy/136 AD individuals). We also assessed 50 healthy/50 Alzheimer's subjects containing MRI-ASL scanning (cerebral blood-flow, CBF) and PET-AV45 scanning (amyloid-load). We performed computational causal connectivity to determine the cause-effect relationship among the parameters. Serum cholic acid in AD subjects substantially decreased to half of controls. Causal-connectivity revealed two novel causative pathways: (i) Decreasing serum CA markedly increased amyloid-load; (ii) Increasing amyloid-load distinctly decreased CBF. We substantiated these two causation pathways respectively with collateral available preclinical observations: (a) increased cholic acid reduces amyloid formation by diminishing gamma-secretase; (b) this decreased amyloid induces capillary-flow enhancement by relaxing vascular pericytes. Indeed, cholic acid can increase amyloid-clearance factor. Neuroimaging-based causal connectivity analysis showed that repositioned pharmacological modulation by cholate derivatives may have appreciable potential as novel window for therapeutic approach to AD. Indicative clinical validation is furnished from available therapeutic trial leads.

01 Dec 2024·Journal of Pharmaceutical and Biomedical Analysis

Integrating sodium cholate-modified MOF hybrid lipase and solubilization of hydrophobic candidates into a step for liganding fishing lipase inhibitors from Nelumbinis Folium

Article

Author: Li, Chenyue ; Chu, Chu ; Hu, Wenxiang ; Zhang, Xindan ; Liu, Ehu ; Ye, Hongwei ; Li, Jiayun ; Lv, Yangbin

Enzyme immobilization by metal organic frameworks (MOFs) is an efficient way for screening active constituents in natural products. However, the enzyme's biocatalysis activity is usually decreased due to unfavorable conformational changes during the immobilization process. In this study, sodium cholate was firstly used as the modifier for zeolitic imidazolate framework-8 (ZIF-8) immobilized lipase to increase both the stability and activity. More importantly, with the help of solubilization of sodium cholate, a total of 3 flavonoids and 6 alkaloids candidate compounds were fished out. Their structures were identified and the enzyme inhibitory activities were verified. In addition, the binding information between the candidate compound and the enzyme was displayed by molecular docking. This study provides valuable information for the improvement of immobilized enzyme activity and functional active ingredients in complicated medicinal plant extracts.

01 Dec 2024·International Journal of Biological Macromolecules

Spectroscopic investigation on the interaction of CHAPS, the zwitterionic steroidal surfactant, with bovine and human serum albumins: A comparative study

Article

Author: Subuddhi, Usharani ; Mohanty, Subhrajit ; Kuldeep

CHAPS, the zwitterionic derivative of cholic acid, has garnered significant research attention owing to its biocompatibility, electro-neutrality over a wide pH range, and non-denaturing nature towards proteins. The escalating demand of CHAPS in biomedical and pharmaceutical industries mandates information on its interaction with various biological macromolecules, especially proteins. The present study involves a comprehensive investigation on the interaction of CHAPS in a wide concentration range (0.001 mM-32 mM), with two extensively used transport proteins, BSA (Bovine Serum Albumin) and HSA (Human Serum Albumin). The study suggests a concentration dependent sequential interaction of CHAPS in discreet stages with the two proteins. A detailed study using warfarin and ibuprofen as site markers provides information about the sites of interaction at different stages. The study indicates significant difference in the effect of CHAPS on these two homologous proteins in terms of their esterase-like activity and effect of chemical denaturant. Moreover, a comparison between CHAPS and its structural bile salt analogues, Sodium cholate and Sodium taurocholate, towards their interaction and effect on the two serum albumins, reveals the mildness of CHAPS towards the proteins, thus endorsing it as a more suitable drug carrier in comparison to its bile salt analogues.

100 Deals associated with Sodium Cholate Hydrate

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