Last update 11 Mar 2026

SHR-5495

Overview

Basic Info

Drug Type
Antibody fusion proteins
Synonyms
SHR 5495, SHR5495
Target
IL-2Rβγ x PD-1
Action
agonists, inhibitors
Mechanism
IL-2Rβγ agonists(Interleukin-2 Rβγ agonists), PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced cancer
Inactive Indication
Locally Advanced Malignant Neoplasm
Originator Organization
Suzhou Suncadia Biopharmaceuticals Co., Ltd.Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Active Organization
Suzhou Suncadia Biopharmaceuticals Co., Ltd.Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SHR-5495
NCT06059508
/ Unknown statusPhase 1
A Multicenter, Open-label Phase I Clinical Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SHR-5495 for Injection in Patients With Advanced Malignancies
100 Clinical Results associated with SHR-5495
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100 Translational Medicine associated with SHR-5495
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100 Patents (Medical) associated with SHR-5495
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1
Literatures (Medical) associated with SHR-5495
01 Oct 2025Science Bulletin
Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional molecule design
100 Deals associated with SHR-5495
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant NeoplasmPhase 1
China
Suzhou Suncadia Biopharmaceuticals Co., Ltd.Suzhou Suncadia Biopharmaceuticals Co., Ltd.
25 Oct 2023
Advanced cancerPhase 1
China
Suzhou Suncadia Biopharmaceuticals Co., Ltd.Suzhou Suncadia Biopharmaceuticals Co., Ltd.
19 Oct 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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