NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), Sodium channels blockers, VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization

China Resources Double-Crane Pharmaceutical Co., Ltd.

Active Organization

China Resources Double-Crane Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (04 Aug 2015),

Hypertension

Regulation-

Structure

Molecular FormulaC7H8ClN3O4S2

InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N

CAS Registry58-93-5

View All Structures (4)

Clinical Trials associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

CTR20140795 / Active, not recruiting

复方利血平氨苯蝶啶胶囊人体生物等效性试验

[Translation] Bioequivalence study of compound reserpine and triamterene capsules in human body

本试验的目的是选择中国健康受试者，以北京星昊医药股份有限公司提供的复方利血平氨苯蝶啶胶囊为受试制剂，按有关BE试验的规定，与国内上市的北京双鹤药业股份有限公司生产的复方利血平氨苯蝶啶片（商品名：0号，参比制剂）进行人体相对生物利用度与生物等效性试验，计算受试制剂的相对生物利用度，比较两种制剂的生物等效性。

[Translation]

The purpose of this study was to select healthy Chinese subjects, use the compound reserpine and triamterene capsules provided by Beijing Xinghao Pharmaceutical Co., Ltd. as the test preparation, and conduct human relative bioavailability and bioequivalence tests on the compound reserpine and triamterene tablets (trade name: No. 0, reference preparation) produced by Beijing Shuanghe Pharmaceutical Co., Ltd. on the domestic market in accordance with the relevant BE test regulations, calculate the relative bioavailability of the test preparation, and compare the bioequivalence of the two preparations.

Start Date08 Apr 2015

Sponsor / Collaborator

Beijing Sunho Pharmaceutical Co., Ltd.

100 Clinical Results associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

100 Translational Medicine associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

100 Patents (Medical) associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

164

Literatures (Medical) associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

01 Jan 2025·Water Research

Fluorescence sensor enabled control of contaminants of emerging concern in reclaimed wastewater using ozone-based treatment processes

Article

Author: Roccaro, Paolo ; Marino, Luigi ; Gagliano, Erica ; Santoro, Domenico

Contaminants of emerging concern (CEC) pose significant challenges to environmental and human health. The development of the wastewater reuse sector, coupled with progressively stringent regulations, needs innovative systems that integrate advanced treatment processes with in-situ and real-time monitoring of CEC. This study investigates the use of a tryptophan-like fluorescence sensor for real-time and online monitoring of CEC within a pilot plant employing O₃-based advanced oxidation processes (AOPs). Two tertiary wastewater effluents (WW-1 and WW-2) were tested, placing the pilot system downstream of two different wastewater treatment plants (WWTPs). Priority substances and micropollutants detected in the investigated water matrixes such as pharmaceuticals, per- and polyfluoroalkyl substances (PFAS) were selected as targeted compounds in this study. Fluorescence degradation was detected in real-time by the sensor, showing a high capability to detect fast changes in water quality induced by oxidation. Furthermore, the real-time fluorescence showed better sensitivity than lab-scale fluorescence in detecting the fast action of hydroxyl radicals (·OH) during the O₃/H₂O₂ process, highlighting the importance of online monitoring. Selected CEC were degraded by AOPs with different percentages of removal efficiency (RE) (0%3 and ·OH. Fluorescence data by online sensor enabled accurate prediction of the removal of a wide spectrum of CEC during O₃ and O₃/H₂O₂ processes (R²≥0.93). Furthermore, real-time fluorescence data were successfully used to predict observed pseudo-first-order rate constants of CEC with O₃ or O₃/H₂O₂. Obtained results suggest that real-time fluorescence monitoring is an excellent tool to control CEC removal during O₃-based AOPs and monitor the transferred ozone in wastewater (R²≥0.94), contributing to the optimization of reagent dose, energy and costs.

01 Dec 2024·Environmental Pollution

Understanding the impact of elevated CO2 and O3 on growth and yield in Indian wheat cultivars: Implications for food security in a changing climate

Article

Author: Gupta, Gereraj Sen ; Agrawal, Shashi Bhushan ; Mishra, Ashish Kumar ; Tiwari, Supriya

The pressing issue of increasing tropospheric ozone (O₃) levels necessitates the development of effective stress management strategies for plant protection. While considerable research has elucidated the adverse impacts of O₃, understanding the combined effects of O₃ and CO₂ requires further investigation. This study focuses on assessing the response of stomatal O₃ flux under various O₃ and CO₂ treatments, individually and in combination, and their repercussions on physiological, growth, and yield attributes in two Indian wheat cultivars, HUW-55 and PBW-550, which exhibit varying levels of sensitivities against elevated O₃. Results indicated significant alterations in stomatal O₃ flux in both O₃-sensitive and tolerant wheat cultivars across different treatments, influencing the overall yield outcomes. Particularly, the ECO₂+EO₃ treatment demonstrated more positive yield protection in the O₃-sensitive cultivar PBW-550, compared to HUW-55 indicating enhanced allocation of photosynthates towards reproductive development in PBW-550, compared to the tolerant cultivar HUW-55, as evidenced by higher harvest index (HI). Furthermore, the study revealed a stronger correlation between yield response and stomatal O₃ flux in PBW-550 (R² = 0.88) compared to HUW-55 (R² = 0.79), as indicated by a steeper regression slope for PBW-550. The research also confirmed the role of elevated CO₂ in reducing stomatal O_3- flux in the tested cultivars, with discernible effects on their respective yield responses. Further experimentation is necessary to confirm these results across different cultivars exhibiting varying sensitivities to O₃. These findings can potentially revolutionize agricultural productivity in regions affected by O₃ stress. The criteria for recommending cultivars for agricultural practices should not be based only on their sensitivity/tolerance to O₃. Still, they should also consider the effect of CO₂ fertilization in the growing area. This experiment offers hope to sustain global food security, as the O₃-sensitive wheat cultivar also showed promising results at elevated CO₂. In essence, this research could pave the way for more resilient agricultural systems in the era of changing climate under elevated O₃ and CO₂ conditions.

01 Dec 2024·Cardiovascular Toxicology

Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone

Article

Author: Farraj, Aimen K ; Grindstaff, Rachel D ; Winnik, Witold M. ; Hazari, Mehdi S. ; Farraj, Aimen K. ; Bruno, Maribel ; Hazari, Mehdi S ; Padgett, William T. ; Padgett, William T ; Grindstaff, Rachel D. ; Nash, Maliha S ; Nash, Maliha S. ; Winnik, Witold M ; Ge, Yue

Inhalation of ambient particulate matter (PM) and ozone (O₃) has been associated with increased cardiovascular morbidity and mortality. However, the interactive effects of PM and O₃ on cardiac dysfunction and disease have not been thoroughly examined, especially at a proteomic level. The purpose of this study was to identify and compare proteome changes in spontaneously hypertensive (SH) rats co-exposed to concentrated ambient particulates (CAPs) and O₃, with a focus on investigating inflammatory and metabolic pathways, which are the two major ones implicated in the pathophysiology of cardiac dysfunction. For this, we measured and compared changes in expression status of 9 critical pro- and anti-inflammatory cytokines using multiplexed ELISA and 450 metabolic proteins involved in ATP production, oxidative phosphorylation, cytoskeletal organization, and stress response using two-dimensional electrophoresis (2-DE) and mass spectrometry (MS) in cardiac tissue of SH rats exposed to CAPs alone, O₃ alone, and CAPs + O₃. Proteomic expression profiling revealed that CAPs alone, O₃ alone, and CAPs + O₃ differentially altered protein expression patterns, and utilized divergent mechanisms to affect inflammatory and metabolic pathways and responses. Ingenuity Pathway Analysis (IPA) of the proteomic data demonstrated that the metabolic protein network centered by gap junction alpha-1 protein (GJA 1) was interconnected with the inflammatory cytokine network centered by nuclear factor kappa beta (NF-kB) potentially suggesting inflammation-induced alterations in metabolic pathways, or vice versa, collectively contributing to the development of cardiac dysfunction in response to CAPs and O₃ exposure. These findings may enhance understanding of the pathophysiology of cardiac dysfunction induced by air pollution and provide testable hypotheses regarding mechanisms of action.

100 Deals associated with Hydrochlorothiazide/Triamterene/Dihydralazine Sulfate/Reserpine

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Indication	Country/Location	Organization	Date
Hypertension	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	04 Aug 2015

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