Last update 22 Feb 2024

Dicyclomine Hydrochloride

Overview

Basic Info

SummaryDicyclomine Hydrochloride, marketed as BENTYL, is an antispasmodic and anticholinergic medication that was approved for use in the USA in 1950 for the treatment of Irritable Bowel Syndrome but has since been withdrawn from the market. The drug is an antagonist of muscarinic acetylcholine receptors (mAChRs). Its chemical name is [bicyclohexyl]-1-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride, with a molecular formula of C19H35NO2•HCl. BENTYL was manufactured by Allergan. As an antispasmodic agent, BENTYL worked by relaxing the muscles in the stomach and intestines, reducing symptoms such as abdominal pain and cramping. As an anticholinergic, BENTYL blocked the effects of acetylcholine, a neurotransmitter that plays a role in intestinal motility.
Drug Type
Small molecule drug
Synonyms
2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate, Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester, Dicyclomine
+ [8]
Target
Mechanism
mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (11 May 1950),
Regulation-
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Structure

Molecular FormulaC19H36ClNO2
InChIKeyGUBNMFJOJGDCEL-UHFFFAOYSA-N
CAS Registry67-92-5
View All Structures (2)

External Link

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
Irritable Bowel SyndromeApprovedUS
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Clinical Trial Result

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