Delving into the Latest Updates on ND-003 with Synapse

Overview

Basic Info

Drug Type

Single-chain FV antibody fragment

Synonyms

Target

CD3 x IL-5Rα

Action

stimulants, inhibitors

Mechanism

CD3 stimulants(T cell surface glycoprotein CD3 stimulants), IL-5Rα inhibitors(Interleukin-5 receptor subunit alpha inhibitors)

Therapeutic Areas

Immune System DiseasesRespiratory Diseases

Active Indication-

Inactive Indication

Asthma

Originator Organization

Numab Innovation AG

Active Organization-

Inactive Organization

Sucampo Pharmaceuticals LLCNumab Innovation AG

License Organization-

Drug Highest PhaseDiscontinuedDiscovery

First Approval Date-

Regulation-

Beneficial microbes are all around us and it remains to be seen, whether all diseases and disorders can be prevented or treated with beneficial microbes. In this study, the presence of various beneficial bacteria were identified from the sediments of Indian major Rivers Ganga and Yamuna from nine different sites using a metagenomic approach. The metagenome sequence analysis using the Kaiju Web server revealed the presence of 69 beneficial bacteria. Phylogenetic analysis among these bacterial species revealed that they were highly diverse. Relative abundance analysis of these bacterial species is highly correlated with different pollution levels among the sampling sites. The PCA analysis revealed that Lactobacillus spp. group of beneficial bacteria are more associated with sediment sampling sites, KAN-2 and ND-3; whereas Bacillus spp. are more associated with sites, FAR-2 and ND-2. This is the first report revealing the richness of beneficial bacteria in the Indian rivers, Ganga and Yamuna. The study might be useful in isolating different important beneficial microorganisms from these river sediments, for possible industrial applications.

100 Deals associated with ND-003

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Asthma	Discovery	Switzerland	Sucampo Pharmaceuticals LLC	-
Asthma	Discovery	Switzerland	Sucampo Pharmaceuticals LLC	-
Asthma	Discovery	Switzerland	Numab Innovation AG	-
Asthma	Discovery	Switzerland	Numab Innovation AG	-

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Clinical Result

Indication

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Approval

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Biosimilar

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