The study aims to evaluate the effectiveness and safety of oral fixed-dose combination of bisoprolol/perindopril in patients with permanent atrial fibrillation

Start Date01 Aug 2020

Sponsor / Collaborator

Aversi Clinic

NCT04588935 / CompletedPhase 2IIT

To Develop and Implement a Method for Medical Prevention of Cardiovascular Diseases Caused by Complex Treatment of Patients With Primary Operated Breast Cancer

To develop a method of medical prevention of cardiovascular diseases caused by cardiotoxicity against the background of complex treatment of patients with primary resectable breast cancer to reduce the risk of cardiovascular complications

Start Date01 Jul 2019

Sponsor / Collaborator-

NCT03730116 / CompletedNot Applicable

Multicenter Observational Open Program. Assessment of the Efficacy and Tolerability of the Fixed-dose Combination of Bisoprolol/Perindopril in Patients With Arterial Hypertension and Stable CAD in Daily Clinical Practice (STYLE)

Study objective - to assess the efficacy, tolerability and adherence of bisoprolol/perindopril FDC in patients with HT and stable CAD in everyday practice.
Type of the program: multicenter, observational, uncontrolled, open program. The program will involve 480 general practitioners (GPs) and cardiologists from the primary care facilities.Each doctor includes four patients. It is planned to include not less than 1920 patients in total.

Start Date14 Nov 2018

Sponsor / Collaborator

Servier Russia

100 Clinical Results associated with Bisoprolol fumarate/Perindopril arginine

100 Translational Medicine associated with Bisoprolol fumarate/Perindopril arginine

100 Patents (Medical) associated with Bisoprolol fumarate/Perindopril arginine

Literatures (Medical) associated with Bisoprolol fumarate/Perindopril arginine

01 Oct 2017·Vnitřní lékařství

COSYREL - an efficient fixed combination for treatment of hypertension, stable ISHD and heart failure

Review

Author: Widimský, Jiří

Fixed combinations of two or three drugs are being frequently used in cardiovascular diseases. This approach markedly increases adherence of the patients to prolonged therapy and thus leads to better control of the diseases. Fixed combinations are often used in hypertension and coronary artery disease (CAD). Cosyrel is the first fixed combination of betablocker (bisoprolol fumarat) and ACE inhibitor (perindopril arginin) available in czech market. The advantage is availability in several concentrations (10 mg/10 mg, 10 mg/5 mg a 5 mg/10 mg a 5 mg/5 mg) , when first indicates bisoprolol dose and the second perindopril. This combination is indicated in arterial hypertension and/or in stable CAD (in patients after myocardial infarction or revascularisation) and/or in dosages 5 mg/5 mg and 5 mg/10 mg in patients with chronic heart failure with systolic dysfunction. This article aimed to evaluate briefly clinical characteristics of this fixed combination. Bisoprol and perindopril arginin have a lot of data indication their positive impact on CV risk and prognosis.Key words: bisoprolol - coronary artery disease - heart failure - hypertension - perindopril.

01 May 2017·Revue medicale de Liege

[Bipressil® : first single-pill combination of bisoprolol and perindopril arginine].

Review

Author: Falque, B ; Gach, O ; Krzesinski, F ; Lancellotti, P ; Canivet, A ; Krzesinski, J-M

In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive role. Coronary artery disease remains the leading cause of mortality in industrialized countries. Unless adapted preventive strategy, notably pharmacological interventions, cardiovascular events in these patients remain high. One reason for this relative failure is represented by non-adherence to treatment. A treatment consisting in an association in one pill of several different molecules should confer a higher treatment compliance and thus efficacy. This article describes the characteristics of the first available dual association between a cardioselective beta-blocker agent, bisoprolol, and an angiotensin-convertase enzyme inhibitor, perindopril arginine.

100 Deals associated with Bisoprolol fumarate/Perindopril arginine

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KEGG	Wiki	ATC	Drug Bank
-	-	C07FB07	-

R&D Status

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Indication	Country/Location	Organization	Date
Coronary Disease	HU	Les Laboratoires Servier SAS	12 Oct 2015
Hypertension	HU	Les Laboratoires Servier SAS	12 Oct 2015

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