Delving into the Latest Updates on Nifedipine/Lidocaine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

Cav2.1 x GR x SCNA x mAChRs x β2-adrenergic receptor

Mechanism

Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors), GR agonists(Glucocorticoid receptor agonists), SCNA blockers(Sodium channel alpha subunit blockers)

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Therapeutic Areas

Digestive System Disorders

Active Indication

Fissure in Ano

Inactive Indication-

Originator Organization

CHIESI Farmaceutici SpA

Active Organization

Seaford Pharmaceuticals, Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Twenty seven patients, 43 to 69 years of age, all with disabling stable angina and positive Bruce stress test, no amendable for revascularization procedures mainly because of poor distal coronary run-off by angiography, were studied with two calcium-channel blockers, the recently developed gallopamil hydrochloride and nifedipine hydrochloride. According to a double blind, cross-over protocol of 12 week duration and after a 2-week washout period, the patients randomly received during 4 weeks 50 mg gallopamil capsules t i d, or 10 mg nifedipine capsules t i d. After a second 2-week wash-out, the alternative drug was administered for another 4 weeks. The number of anginal episodes decreased significantly (p less than 0.01) with both treatments (from 6.4 to 1.8 crisis with gallopamil and from 6.2 to 2.1 with nifedipine). Heart rate (HR) was progressively reduced with gallopamil (-7.9%, p less than 0.05) but increased with nifedipine (+5.7%) in relation to basal figures. Both medications reduced the level of ST depression during the stress test (52.4% with gallopamil and 41.8% with nifedipine, N.S.). The time for angina at the stress test increased 92.5% with gallopamil and 40.7% with nifedipine (p less than 0.05). HR systolic product at peak exercise was 23,101 with gallopamil and 24,906 with nifedipine (p less than 0.001). Both calcium-channel blockers are drugs with significant anti-anginal effects in patients with stable, disabling angina.(ABSTRACT TRUNCATED AT 250 WORDS)

100 Deals associated with Nifedipine/Lidocaine Hydrochloride

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