Delving into the Latest Updates on Costimulatory CD28/CD3-bispecific antibodies(Regeneron) with Synapse

Overview

Basic Info

Drug Type

Bispecific T-cell Engager (BiTE)

Synonyms-

Target

CD28 x CD3

Action

agonists, stimulants

Mechanism

CD28 agonists(T-cell-specific surface glycoprotein CD28 agonists), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Regeneron Pharmaceuticals, Inc.

Active Organization-

Inactive Organization

Regeneron Pharmaceuticals, Inc.

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

Author: Dudgeon, Drew ; Yancopoulos, George D. ; Wang, Bei ; Ye, Xuan ; Ramos, Ilyssa ; Ajithdoss, Dharani ; Thurston, Gavin ; Rafique, Ashique ; Smith, Eric ; Poueymirou, William ; Canova, Lauren ; Hermann, Aynur ; Olson, William ; Yu, Kevin ; Chiu, Danica ; Murphy, Andrew J. ; Martin, Joel ; Siao, Chia-Jen ; Poon, Patrick ; Oyejide, Adelekan ; Potocky, Terra ; Vazzana, Kristin ; Kirshner, Jessica R. ; Lazo, Miguel ; Oswald, Erin ; Ullman, Erica ; Kim, Julie ; MacDonald, Douglas ; Havel, Lauren ; Godin, Stephen ; Crawford, Alison ; Pawashe, Arpita ; Ahmed, Hassan ; Stokes Oristian, Nicole ; Skokos, Dimitris ; Provoncha, Kathleen ; Slim, Rabih ; Lin, John ; Wu, Qi ; Ram, Priyanka ; Warsaw, Jacqueline J. ; Haber, Lauric ; Huang, Tammy ; Sleeman, Matthew A. ; Herlihy, Evan ; Waite, Janelle C. ; Golubov, Jacquelynn

CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy.

100 Deals associated with Costimulatory CD28/CD3-bispecific antibodies(Regeneron)

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	United States	Regeneron Pharmaceuticals, Inc.	08 Jan 2020

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.

login

or

view full example data

Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.

login

or

view full example data

Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.

login

or

view full example data

Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.

login

or

view full example data

Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.

login

or

view full example data

Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

login

or

view full example data