Delving into the Latest Updates on Ethyl Piperidinoacetylaminobenzoate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ethyl p - Piperidinoacetylaminobenzoate, Sulcain, スルカイン

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Gastritis

Inactive Indication-

Originator Organization

Nippon Shinyaku Co., Ltd.

Active Organization

Nippon Shinyaku Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (31 Aug 2007),

Gastritis

Regulation-

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Structure/Sequence

Molecular FormulaC16H22N2O3

InChIKeyQLGIFPJNYPWBMQ-UHFFFAOYSA-N

CAS Registry41653-21-8

A satisfactory separation of 14 local anesthetics such as benzocaine [94-09-7], lidocaine [137-58-6], dibucaine [85-79-0] and cocaine [50-36-2] was achieved by gas chromatog. using 2% OV-17, 3% XE-60, and 0.5% Thermal-3 columns.In the mass spectra of these drugs, the mol. ion appeared as the peaks with a low intensity except in the case of benzocaine, cocaine, and tropacocaine [537-26-8].Most of the intensive peaks were present in the relatively low mass region.Many characteristic fragments based on the structure of these drugs were observedCombination of gas chromatog. and mass spectrometry appears to be a useful way for the determination of anesthetics in body fluids.

01 Jan 1963·Nihon yakurigaku zasshi. Folia pharmacologica Japonica

Aminoacylamino基を有する新合成化合物の鎮痙作用

Article

Author: Nanya, Hirokazu

Derivatives of Et 4-(aminoacylamido)benzoate were pharmacol. examinedEt 4-(2-piperidinopropionamido)benzoate (I), Et 4-(piperidinoacetamido)benzoate and Et 4-(2-butylaminopropionamido)benzoate showed a spasmolytic activity comparable with avacan in the excised guinea-pig intestine contracted by BaCl₂ or acetylcholine.They lacked obvious effects on blood pressure and pilocarpine-induced salivation in rabbits and on pupil size in mice.Antispasmodic activity was not increased by converting tertiary amine compounds into quaternary ammonium salts.However, some onium compounds showed ganglionic blocking action as potent as hexamethonium in the sympathetic-nictitating membrane system in cats.Subcutaneous L.D.₅₀ for mice of I-HCl was 1.2 g./kg. and that of I MeBr was 170 mg./kg.

100 Deals associated with Ethyl Piperidinoacetylaminobenzoate

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