Last update 30 Oct 2025

EX-105

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Anti-CD3/anti-PD-1 bispecific antibody, EX 105, EX-105
+ [1]
Target
CD276 x CD3
Action
inhibitors, stimulants
Mechanism
CD276 inhibitors(CD276 antigen inhibitors), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease
Active Indication
Advanced Malignant Solid NeoplasmPancreatic Cancer
Inactive Indication-
Originator Organization
Excelmab, Inc.Excelmab, Inc.
Active Organization
Excelmab, Inc.Excelmab, Inc.
Inactive Organization-
License Organization-
Drug Highest PhaseIND Approval
First Approval Date-
Regulation-
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Related

100 Clinical Results associated with EX-105
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100 Translational Medicine associated with EX-105
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100 Patents (Medical) associated with EX-105
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1
Literatures (Medical) associated with EX-105
02 Feb 2017BloodQ1 · MEDICINE
An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia
Q1 · MEDICINE
100 Deals associated with EX-105
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmIND Approval
China
Excelmab, Inc.Excelmab, Inc.
15 Mar 2023
Pancreatic CancerPreclinical
United States
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
Pancreatic CancerPreclinical
China
Excelmab, Inc.Excelmab, Inc.
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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