Last update 08 Nov 2025

FFT-135

Overview

Basic Info

Drug Type
Degrader-antibody conjugates
Synonyms
FFT 135, FFT135
Target
EF-1A x GSPT1 x GSPT2
Action
degraders
Mechanism
EF-1A degraders(HBS1 like translational GTPase degraders), GSPT1 degraders(G1 to S phase transition 1 degraders), GSPT2 degraders(G1 to S phase transition 2 degraders)
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Colorectal CancerHepatocellular CarcinomaStomach Cancer
Inactive Indication-
Originator Organization
F5 Therapeutics, Inc.F5 Therapeutics, Inc.
Active Organization
F5 Therapeutics, Inc.F5 Therapeutics, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

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Related

100 Clinical Results associated with FFT-135
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100 Translational Medicine associated with FFT-135
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100 Patents (Medical) associated with FFT-135
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100 Deals associated with FFT-135
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal CancerPreclinical
United States
F5 Therapeutics, Inc.F5 Therapeutics, Inc.
10 Jan 2024
Hepatocellular CarcinomaPreclinical
United States
F5 Therapeutics, Inc.F5 Therapeutics, Inc.
10 Jan 2024
Stomach CancerPreclinical
United States
F5 Therapeutics, Inc.F5 Therapeutics, Inc.
10 Jan 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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