Delving into the Latest Updates on Poliomyelitis Vaccine Type I Type III in Dragee Candy (Human Diploid Cell), Live(Institute of Medical Biology Chinese Academy of Medical Sciences) with Synapse

Overview

Basic Info

Drug Type

Live attenuated vaccine, Prophylactic vaccine

Synonyms-

Target-

Mechanism

Immunostimulants

Therapeutic Areas

Infectious DiseasesNervous System DiseasesOther Diseases

Active Indication

Poliomyelitis

Inactive Indication-

Originator Organization

Zhong Guo Yi Xue Ke Xue Yuan Yi Xue Sheng Wu Xue Yan Jiu Suo

Active Organization

Zhong Guo Yi Xue Ke Xue Yuan Yi Xue Sheng Wu Xue Yan Jiu Suo

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (29 Oct 2018),

Poliomyelitis

Regulation-

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To evaluate the antibody immunity persistence of type 1 + type 3 oral attenuated live polio vaccine (human diploid cells) and type 1 + type 3 polio vaccine sugar pills (human diploid cells) combined with IPV sequential immunization, and to explore the rationality of booster immunization at 48 months of age for each sequential immunization program.

Start Date03 Dec 2017

Sponsor / Collaborator

Zhong Guo Yi Xue Ke Xue Yuan Yi Xue Sheng Wu Xue Yan Jiu Suo

CTR20160169 / Active, not recruitingPhase 3IIT

随机、盲法、平行对照试验评价双价脊髓灰质炎减毒活疫苗（人二倍体细胞）与IPV联合序贯免疫临床试验

[Translation] A randomized, blinded, parallel controlled trial to evaluate the sequential immunization of a bivalent attenuated live poliomyelitis vaccine (human diploid cells) combined with IPV

主要目标：比较2剂cIPV/sIPV+1剂tOPV（液体剂型/糖丸）与2剂cIPV/sIPV+1剂bOPV(液体剂型/糖丸)序贯接种后Ⅰ、Ⅱ、Ⅲ型脊髓灰质炎抗体阳转率和抗体水平。次要目标：（1）比较1剂cIPV/sIPV+2剂tOPV（液体剂型/糖丸）与2剂cIPV/sIPV+1剂bOPV(液体剂型/糖丸)序贯接种后Ⅰ、Ⅱ、Ⅲ型脊髓灰质炎抗体阳转率和抗体水平。（2）评价bOPV（液体剂型/糖丸）疫苗的安全性。

[Translation]

Primary objective: To compare the positive conversion rate and antibody levels of polio antibodies of types I, II, and III after sequential vaccination with 2 doses of cIPV/sIPV + 1 dose of tOPV (liquid dosage form/sugar pill) and 2 doses of cIPV/sIPV + 1 dose of bOPV (liquid dosage form/sugar pill). Secondary objectives: (1) To compare the positive conversion rate and antibody levels of polio antibodies of types I, II, and III after sequential vaccination with 1 dose of cIPV/sIPV + 2 doses of tOPV (liquid dosage form/sugar pill) and 2 doses of cIPV/sIPV + 1 dose of bOPV (liquid dosage form/sugar pill). (2) To evaluate the safety of bOPV (liquid dosage form/sugar pill) vaccine.

Start Date15 Sep 2015

Sponsor / Collaborator

Zhong Guo Yi Xue Ke Xue Yuan Yi Xue Sheng Wu Xue Yan Jiu Suo

CTR20160167 / Active, not recruitingPhase 3IIT

随机、盲法、平行对照试验评价双价脊髓灰质炎减毒活疫苗（人二倍体细胞）与IPV联合序贯免疫临床试验

[Translation] A randomized, blinded, parallel controlled trial to evaluate the sequential immunization of a bivalent attenuated live poliomyelitis vaccine (human diploid cells) combined with IPV

主要目标：比较2剂cIPV/sIPV+1剂tOPV（液体剂型/糖丸）与2剂cIPV/sIPV+1剂bOPV(液体剂型/糖丸)序贯接种后Ⅰ、Ⅱ、Ⅲ型脊髓灰质炎抗体阳转率和抗体水平。次要目标：（1）比较1剂cIPV/sIPV+2剂tOPV（液体剂型/糖丸）与2剂cIPV/sIPV+1剂bOPV(液体剂型/糖丸)序贯接种后Ⅰ、Ⅱ、Ⅲ型脊髓灰质炎抗体阳转率和抗体水平。（2）评价bOPV（液体剂型/糖丸）疫苗的安全性。

[Translation]

Primary objective: To compare the positive conversion rate and antibody levels of polio antibodies of types I, II, and III after sequential vaccination with 2 doses of cIPV/sIPV + 1 dose of tOPV (liquid dosage form/sugar pill) and 2 doses of cIPV/sIPV + 1 dose of bOPV (liquid dosage form/sugar pill). Secondary objectives: (1) To compare the positive conversion rate and antibody levels of polio antibodies of types I, II, and III after sequential vaccination with 1 dose of cIPV/sIPV + 2 doses of tOPV (liquid dosage form/sugar pill) and 2 doses of cIPV/sIPV + 1 dose of bOPV (liquid dosage form/sugar pill). (2) To evaluate the safety of bOPV (liquid dosage form/sugar pill) vaccine.

Start Date15 Sep 2015

Sponsor / Collaborator

Zhong Guo Yi Xue Ke Xue Yuan Yi Xue Sheng Wu Xue Yan Jiu Suo

100 Clinical Results associated with Poliomyelitis Vaccine Type I Type III in Dragee Candy (Human Diploid Cell), Live(Institute of Medical Biology Chinese Academy of Medical Sciences)

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100 Translational Medicine associated with Poliomyelitis Vaccine Type I Type III in Dragee Candy (Human Diploid Cell), Live(Institute of Medical Biology Chinese Academy of Medical Sciences)

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100 Patents (Medical) associated with Poliomyelitis Vaccine Type I Type III in Dragee Candy (Human Diploid Cell), Live(Institute of Medical Biology Chinese Academy of Medical Sciences)

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100 Deals associated with Poliomyelitis Vaccine Type I Type III in Dragee Candy (Human Diploid Cell), Live(Institute of Medical Biology Chinese Academy of Medical Sciences)

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