GS1-144

Main study objectives: To evaluate the safety and tolerability of GS1-144 tablets after single and multiple oral doses; Secondary study objectives: 1) To evaluate the pharmacokinetic (PK) characteristics of GS1-144 tablets after single and multiple oral administration in healthy subjects; 2) To evaluate the effect of high-fat meal on PK; 3) To evaluate the level of QT/QTc interval changes after oral administration of GS1-144 tablets in healthy subjects. Exploratory study objectives: 1) To preliminarily evaluate the metabolic characteristics of GS1-144 tablets in humans; 2) To evaluate the pharmacodynamic (PD) characteristics of GS1-144 tablets in healthy postmenopausal women.