Last update 08 May 2025

Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
CTLA-4/PD-1 antibodies expressing mesoCAR-T
Target
CTLA4 x MSLN x PD-1
Action
inhibitors, modulators
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors), MSLN modulators(Mesothelin modulators), PD-1 inhibitors(Programmed cell death protein 1 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Advanced Malignant Solid NeoplasmMesothelin positive Solid Tumors
Originator Organization
Shanghai Cell Therapy Group Co., Ltd.Shanghai Cell Therapy Group Co., Ltd.
Active Organization-
Inactive Organization
Shanghai Cell Therapy Group Co., Ltd.Shanghai Cell Therapy Group Co., Ltd.
License Organization-
Drug Highest PhasePendingPhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)
NCT03182803
/ Unknown statusPhase 1/2
A Clinical Study of CTL-A4 and PD-1 Antibodies Expressing Mesothelin-CAR-T Cells for Patients With Mesothelin Positive Advanced Solid Tumors
100 Clinical Results associated with Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)
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100 Translational Medicine associated with Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)
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100 Patents (Medical) associated with Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)
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100 Deals associated with Anti-CTLA-4 and PD-1 CAR-T cell therapy(Shanghai Cell Therapy Group Co. Ltd.)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
Shanghai Cell Therapy Group Co., Ltd.Shanghai Cell Therapy Group Co., Ltd.
07 Jun 2017
Mesothelin positive Solid TumorsPhase 2
China
Shanghai Cell Therapy Group Co., Ltd.Shanghai Cell Therapy Group Co., Ltd.
07 Jun 2017
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Clinical Result

Indication
Phase
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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