Prepare an ointment from Azadirachta indica leaves extract and its apply on palmer arsenical keratosis patient, for 12 weeks. After intervention, effect of the ointment will be observed by measuring the nodule (before and after apply the ointment)

Start Date20 Oct 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

NCT02943759

/ CompletedPhase 2/3IIT

Resolution of Pain and Swelling After the Use of Neem Leaf Extract (Azadirachta Indica) Compared to Chlorhexidine Gluconate as an Intracanal Irrigant in Necrotic Primary Molar Teeth in Children Undergoing Pulpectomy Treatment: A Randomised Controlled Trial

The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy treatment for children.

Start Date01 Dec 2016

Sponsor / Collaborator

Cairo University

100 Clinical Results associated with Azadirachta indica leaves extract

100 Translational Medicine associated with Azadirachta indica leaves extract

100 Patents (Medical) associated with Azadirachta indica leaves extract

Literatures (Medical) associated with Azadirachta indica leaves extract

01 Dec 2024·Molecular Biology Reports

Therapeutic potential of targeting AKR1C2 in the treatment of prostate cancer

Review

Author: Nie, Mingyi ; Wang, Xueni ; Liu, Peng ; Li, Tian

Prostate cancer development and progression are driven by androgens, and changes in androgen metabolic pathways can lead to prostate cancer progression or remission. AKR1C2 is a member of the aldo-keto reductase superfamily and plays an important role in the metabolism of steroids and prostaglandins. Alterations in the expression and activity of AKR1C2 affect the homeostasis of active androgens, which in turn affects the progression of prostate cancer. AKR1C2 reduces the highly active dihydrotestosterone to the less active 3α-diol in the prostate, resulting in lower androgen levels. Whereas the expression of AKR1C2 is significantly reduced in prostate cancer tissues relative to normal prostate tissues, this results in a weakening of the dihydrotestosterone metabolic inactivation pathway, leading to the retention of dihydrotestosterone in the prostate cancer cells, which promotes the progress of prostate cancer. Given the critical role of AKR1C2 in prostate cancer cells, targeting AKR1C2 for the treatment of prostate cancer may be an effective strategy. It has been demonstrated that curcumin and neem leaf extract effectively inhibit prostate cancer in vitro and in vivo by modulating AKR1C2.

100 Deals associated with Azadirachta indica leaves extract

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Prostatic Cancer	Preclinical	China	Guangxi University of Chinese Medicine	18 Sep 2024
Arsenical keratosis	Preclinical	Bangladesh	Bangabandhu Sheikh Mujib Medical University	20 Oct 2019
Pain	Preclinical	Egypt	Cairo University	01 Dec 2016
Periapical Abscess	Preclinical	Egypt	Cairo University	01 Dec 2016
Tumescence	Preclinical	Egypt	Cairo University	01 Dec 2016

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