Delving into the Latest Updates on HP-515 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

HP515

Target

THR-β

Mechanism

THR-β inhibitors(Thyroid hormone receptor beta-1 inhibitors)

Therapeutic Areas

Digestive System Disorders

Active Indication

Nonalcoholic Steatohepatitis

Inactive Indication-

Originator Organization

Hinova Pharmaceuticals, Inc.

Active Organization

Hinova Pharmaceuticals, Inc.Hinova Pharmaceuticals (Usa) Inc

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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主要目的 1. 评价HP515片在健康受试者中单次及多次口服给药的安全性和耐受性； 2. 评价食物在健康受试者中对HP515片药代动力学的影响。次要目的 1. 评价HP515片在健康受试者中单次及多次口服给药的药代动力学特征； 2. 评价HP515片在健康受试者中单次及多次口服给药的药效动力学特征；探索性目的探索口服HP515后血浆中的可能的代谢产物及主要代谢产物浓度（如有）。

[Translation]

Main purpose 1. To evaluate the safety and tolerability of single and multiple oral administration of HP515 tablets in healthy subjects; 2. To evaluate the effect of food on the pharmacokinetics of HP515 tablets in healthy subjects. Secondary purpose 1. To evaluate the pharmacokinetic characteristics of single and multiple oral administration of HP515 tablets in healthy subjects; 2. To evaluate the pharmacodynamic characteristics of single and multiple oral administration of HP515 tablets in healthy subjects; Exploratory purpose To explore the possible metabolites and the concentration of major metabolites (if any) in plasma after oral administration of HP515.

Start Date-

Sponsor / Collaborator