Last update 28 Apr 2025

LCI-139

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LCI 139, LCI139
Target
Aurora A x Aurora B x CDK4 x CDK6 x CDK9 x PI3Kα x PI3Kγ x PI3Kδ
Action
inhibitors
Mechanism
Aurora A inhibitors(Serine/threonine-protein kinase Aurora-A inhibitors), Aurora B inhibitors(Serine/threonine-protein kinase Aurora-B inhibitors), CDK4 inhibitors(Cyclin-dependent kinase 4 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [4]
Active Indication
Ewing SarcomaNon-Small Cell Lung CancerEndometrial Carcinoma+ [1]
Inactive Indication-
Originator Organization
Atrium Health, Inc.Atrium Health, Inc.
Active Organization
Atrium Health, Inc.Atrium Health, Inc.Levine Cancer Institute
Inactive Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with LCI-139
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100 Translational Medicine associated with LCI-139
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100 Patents (Medical) associated with LCI-139
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100 Deals associated with LCI-139
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ewing SarcomaPreclinical
United States
Atrium Health, Inc.Atrium Health, Inc.
28 Apr 2025
Non-Small Cell Lung CancerPreclinical
United States
Levine Cancer Institute
27 Apr 2025
Endometrial CarcinomaPreclinical
United States
Atrium Health, Inc.Atrium Health, Inc.
08 Apr 2024
Mantle-Cell LymphomaPreclinical
United States
Atrium Health, Inc.Atrium Health, Inc.
12 Dec 2023
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Clinical Result

Indication
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Approval

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Regulation

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