Last update 23 Nov 2024
Spongosine
Last update 23 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms BVT 115959, BVT-115959, BVT.115959 + [1] |
Target |
Mechanism A2aR agonists(Adenosine A2a receptor agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
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Structure
Molecular FormulaC11H15N5O5 |
InChIKeyAJACDNCVEGIBNA-KQYNXXCUSA-N |
CAS Registry24723-77-1 |
Related
2
Clinical Trials associated with SpongosineA double-blind, placebo-controlled, randomized, parallel-group study evaluating the efficacy and tolerability of oral BVT.115959, a novel A2A agonist, versus placebo in the treatment of diabetic neuropathic pain
A Double-blind, Placebo-controlled, Randomized, Parallel-group Study Evaluating the Efficacy and Tolerability of Oral BVT.115959, a Novel A2A Agonist, Versus Placebo in the Treatment of Diabetic Neuropathic Pain
100 Clinical Results associated with Spongosine
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100 Translational Medicine associated with Spongosine
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100 Patents (Medical) associated with Spongosine
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2
Literatures (Medical) associated with Spongosine27 Mar 2015Journal of natural productsQ2 · BIOLOGY
Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta
Q2 · BIOLOGY
Article
Author: Lee, John ; Bertin, Matthew J. ; Dorrestein, Pieter C. ; Korobeynikov, Anton ; Gerwick, Lena ; Schwartz, Sarah L. ; Gerwick, William H.
Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.
01 Mar 2011Mini reviews in medicinal chemistryQ3 · MEDICINE
Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates
Q3 · MEDICINE
Review
Author: Proksch, P. ; Ebada, S. S.
Natural Guanidines from marine invertebrates represent a group of bioactive secondary metabolites that revealed prominent pharmacological activities such as antimicrobial, antiproliferative, analgesic, and anti-coagulant properties. Acyclovir (Zovirax(®)), the first guanidine-derived pharmaceutical for the treatment of herpes infections since late 1970s, was synthesized based on a marine arabinosyl nucleoside, spongosine. Recently, ziconotide (Prialt(®)), a synthetic form of the marine-derived peptide (ω-conotoxin MVIIA) comprising a guanidine moiety, has been approved for the treatment of chronic pain. This review surveys over 130 compounds of guanidine-containing secondary metabolites from marine invertebrates with emphasis on their pharmacological significance and structure-activity relationships.
100 Deals associated with Spongosine
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | Spongosine | - | - |
R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Diabetic peripheral neuropathic pain | Phase 2 | CZ | 01 May 2007 | |
| Diabetic peripheral neuropathic pain | Phase 2 | DE | 01 May 2007 | |
| Diabetic peripheral neuropathic pain | Phase 2 | ZA | 01 May 2007 | |
| Diabetic Neuropathies | Phase 2 | - | - | |
| Diabetic Neuropathies | Phase 2 | - | - | |
| Inflammatory pain | Preclinical | GB | - |
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