A Double-blind, Placebo-controlled, Randomized, Parallel-group Study Evaluating the Efficacy and Tolerability of Oral BVT.115959, a Novel A2A Agonist, Versus Placebo in the Treatment of Diabetic Neuropathic Pain

The purpose of this study is to evaluate the efficacy and tolerability of BVT.115959 in diabetic patients with neuropathic pain who are either not on analgesia or are on stable analgesia in the month prior to entering the study.

Start Date01 May 2007

Sponsor / Collaborator

Swedish Orphan Biovitrum AB

EUCTR2006-005967-25-CZ / Not yet recruitingNot Applicable

A double-blind, placebo-controlled, randomized, parallel-group study evaluating the efficacy and tolerability of oral BVT.115959, a novel A2A agonist, versus placebo in the treatment of diabetic neuropathic pain

Start Date06 Mar 2007

Sponsor / Collaborator

Swedish Orphan Biovitrum AB

100 Clinical Results associated with Spongosine

100 Translational Medicine associated with Spongosine

100 Patents (Medical) associated with Spongosine

Literatures (Medical) associated with Spongosine

27 Mar 2015·Journal of natural productsQ2 · BIOLOGY

Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta

Q2 · BIOLOGY

Article

Author: Lee, John ; Bertin, Matthew J. ; Dorrestein, Pieter C. ; Korobeynikov, Anton ; Gerwick, Lena ; Schwartz, Sarah L. ; Gerwick, William H.

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

01 Mar 2011·Mini reviews in medicinal chemistryQ3 · MEDICINE

Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates

Q3 · MEDICINE

Review

Author: Proksch, P. ; Ebada, S. S.

Natural Guanidines from marine invertebrates represent a group of bioactive secondary metabolites that revealed prominent pharmacological activities such as antimicrobial, antiproliferative, analgesic, and anti-coagulant properties. Acyclovir (Zovirax(®)), the first guanidine-derived pharmaceutical for the treatment of herpes infections since late 1970s, was synthesized based on a marine arabinosyl nucleoside, spongosine. Recently, ziconotide (Prialt(®)), a synthetic form of the marine-derived peptide (ω-conotoxin MVIIA) comprising a guanidine moiety, has been approved for the treatment of chronic pain. This review surveys over 130 compounds of guanidine-containing secondary metabolites from marine invertebrates with emphasis on their pharmacological significance and structure-activity relationships.

100 Deals associated with Spongosine

External Link

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetic peripheral neuropathic pain	Phase 2	CZ	Swedish Orphan Biovitrum AB	01 May 2007
Diabetic peripheral neuropathic pain	Phase 2	DE	Swedish Orphan Biovitrum AB	01 May 2007
Diabetic peripheral neuropathic pain	Phase 2	ZA	Swedish Orphan Biovitrum AB	01 May 2007
Diabetic Neuropathies	Phase 2	-	Sobi Analytics Ltd.	-
Diabetic Neuropathies	Phase 2	-	Zhejiang Crownmab Biotech Co. Ltd.	-
Inflammatory pain	Preclinical	GB	Swedish Orphan Biovitrum AB	-

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