Last update 15 Sep 2026

VBC106

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
VBC-106
Target
FOLR1 x MSLN x Top I
Action
antagonists, inhibitors
Mechanism
FOLR1 antagonists(Folate receptor alpha antagonists), MSLN inhibitors(Mesothelin inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease+ [3]
Active Indication
Advanced Malignant Solid NeoplasmEndometrial CarcinomaHER2 Positive Gastrointestinal Neoplasms+ [4]
Inactive Indication-
Originator Organization
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
Active Organization
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,LtdVelaVigo Bio Inc
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with VBC106
NCT07686068
/ Not yet recruitingPhase 1/2
Phase 1/2a Open-Label Clinical Trial Evaluating VBC106, an FRα- and MSLN-Directed Bispecific Antibody Drug Conjugate, in Participants With Advanced Malignant Solid Tumors
100 Clinical Results associated with VBC106
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100 Translational Medicine associated with VBC106
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100 Patents (Medical) associated with VBC106
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100 Deals associated with VBC106
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
United States
VelaVigo Bio Inc
18 Aug 2026
Advanced Malignant Solid NeoplasmPhase 2
Australia
VelaVigo Bio Inc
18 Aug 2026
Endometrial CarcinomaIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
HER2 Positive Gastrointestinal NeoplasmsIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
Mesothelioma, MalignantIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
Ovarian CancerIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
Triple Negative Breast CancerIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
Non-Small Cell Lung CancerIND Approval
China
Velavigo Shanghai Pharmaceutical Co.,LtdVelavigo Shanghai Pharmaceutical Co.,Ltd
02 Sep 2026
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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