Personal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with ¹³C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection.

01 Apr 2025·International Journal of Biological Macromolecules

Multipurpose packaging system based on intelligent carboxymethyl cellulose film and activated cellulose acetate electrospun nanofibers for seafoods

Article

Author: Ahangari, Hossein ; Amjadi, Sajed ; Ebrahimi, Alireza ; Ehsani, Ali

The objective of this research is to develop a natural macromolecules-based smart double-layer film using carboxymethyl cellulose (CMC) film containing pomegranate peel anthocyanins (PPA) and cellulose acetate nanofibers (CANFs) with Artemisia sieberi Besser essential oil-loaded nanostructured lipid carriers (ABNLCs). Based on the performance as a color indicator, and other studied properties, the CMC/PPA 8 % film was selected as the optimized film. The double-layer film was constructed by electrospinning the CANFs containing ABNLCs on the optimized CMC film. The average diameter of the CANFs was 332.87 ± 65.80 nm. Furthermore, the XRD patterns of CA/ABNLCs NFs showed many diffraction peaks that the sharp peaks at 2θ of 25° and 28°, indicating its crystalline structure. In addition, the Young's modulus and elongation at break point values of the CMC/PPA 8 % double-layered film were reached to 151.47 MPa and 11.39 %, respectively. The intelligent layer demonstrated acceptable performance in detecting the freshness of shrimp and fish fillets. The double-layered film showed good antibacterial activity with inhibition zones of 10 and 12 mm against E. coli and S. aureus pathogens, respectively.

11 Mar 2025·ACS Nano

Nanoparticle-Mediated Toll-Like Receptor Activation and Dual Immune Checkpoint Downregulation for Potent Cancer Immunotherapy

Article

Author: Weichselbaum, Ralph R. ; Zhao, Zhihao ; Lin, Wenbin ; Jiang, Xiaomin ; Zanni, Richard ; Liu, Jing

Dual blockade of CD47 and PD-L1 immune checkpoints has shown potential in cancer treatment, but its clinical application is hindered by the on-target off-tumor immunotoxicities of monoclonal antibodies. Herein, we report a core-shell nanoparticle, PPA/HG, comprising polyinosinic: polycytidylic acid (PPA) in the core and a cholesterol-conjugated prodrug of 3-(hydroxyolinoyl)glycine (HG) on the shell, for potent cancer immunotherapy. PPA/HG shows a long half-life in the bloodstream to efficiently accumulate in tumors, where PPA/HG rapidly releases HG and PPA. HG inhibits the histone lysine demethylase 3A/c-Myc transduction for effective CD47 and PD-L1 downregulation in cancer cells while PPA activates toll-like receptor 3 in dendritic cells and tumor-associated macrophages to promote dendritic cell maturation and macrophage repolarization. PPA/HG promotes the infiltration and activation of effector T lymphocytes, meanwhile decreasing the population of immunosuppressive regulatory T cells. Systemic administration of PPA/HG significantly inhibits the progression of orthotopic triple-negative breast cancer and pancreatic ductal adenocarcinoma with minimal side effects.

100 Deals associated with Pipemidic Acid Hydrate

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KEGG	Wiki	ATC	Drug Bank
D01531	Pipemidic Acid Hydrate	J01MB04	DB13823

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Infections	China	Jiangsu Nhwa Pharmaceutical Co., Ltd.	01 Jan 1984
Bacterial Infections	China	Hunan Xiangquan Pharmaceutical Co., Ltd.	01 Jan 1984
Bacterial Infections	China	Haerbin Taihua Pharmaceutical Co. Ltd.	01 Jan 1984
Urinary Tract Infections	China	Jiangsu Nhwa Pharmaceutical Co., Ltd.	01 Jan 1984
Urinary Tract Infections	China	Hunan Xiangquan Pharmaceutical Co., Ltd.	01 Jan 1984
Urinary Tract Infections	China	Haerbin Taihua Pharmaceutical Co. Ltd.	01 Jan 1984
Cystitis	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Enteritis	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Otitis Media	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Prostatitis	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Pyelonephritis	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Sinusitis	Japan	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978

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