The inhibitory activities of phaeosphaeride A (PPA), phaeosphaeride B, and four synthetic derivatives against phosphorylation of signal transducer and activator of transcription 3 (STAT3) and cell proliferation in cervical (HeLa) and breast (MDA-MB-231) cancer cells were evaluated. PPA inhibited IL-6-induced STAT3 phosphorylation and cell proliferation at similar concentrations. The structure-activity relationship studies revealed that the enantiomer of PPA was the most potent of the evaluated phaeosphaerides in both inhibiting STAT3 phosphorylation and cell growth. PPA clearly inhibited the IL-6-activated STAT3 signaling pathway. However, the presence or absence of activation of the STAT3 signaling pathway in cells showed no relationship to the antiproliferative activity. Notably, the possible covalent bond-forming ability of PPA was critical for its biological activities.

01 Nov 2024·Operative Dentistry

Effect of Surface Treatments on Shear-bond Strength of Glass Ionomer Cements to Silver Diamine Fluoride-treated Simulated Carious Dentin

Article

Author: Koh, WT ; Yahya, NA ; Yeoh, OT ; Yap, AU

SUMMARYObjectives:This study investigated the effect of different surface treatments on the shear bond strength (SBS) and failure modes of self-cured (SC) and light-cured (LC) high-viscosity glass ionomer cements (HVGICs) to silver diamine fluoride (SDF)-treated simulated carious dentin (SCD).Methods and Materials:Extracted human premolars were sectioned and pH cycled for 10 days to simulate carious dentin. The demineralized specimens were treated with 38% SDF (Riva Star) for 2 minutes, washed, stored in deionized distilled water at 37°C for 2 weeks, and subjected to the following surface treatments (n=14): T1 – no treatment (control); T2 – 10 seconds polyacrylic acid (PAA); T3 – 5 seconds phosphoric acid (PPA); T4 – 5 seconds PPA plus universal adhesive (Zipbond); and T5 – 5 seconds PPA plus resin-modified GIC adhesive (Riva bond LC). SC (Riva Self-cure HV) and LC (Riva Light-cure HV) HVGICs were applied to the conditioned specimens and stored in artificial saliva at 37°C for 1 week. SBS and failure modes were subsequently determined. Statistical analyses were performed using Kruskal-Wallis/post-hoc Mann-Whitney U and Chi-square tests (α=0.05).Results:The highest SBS was observed when SC and LC were restored with T2 and T5, respectively. Significant differences in SBS were as follows: SC – T2, T1 > T5, T3; LC – T5, T4, T3 > T2. SC generally exhibited adhesive failures, while LC presented both adhesive and mixed failures.Conclusion:The preferred method for preparing SDF-treated carious dentin before restoration application is PAA for SC and PPA plus RMGIC adhesive for LC HVGICs.

01 Nov 2024·Drug and Alcohol Dependence

Investigation into the biomolecular bases of blunted cocaine-induced glutamate release within the nucleus accumbens elicited by adolescent exposure to phenylpropanolamine

Article

Author: Miller, Bailey W ; Miller, Bailey W. ; Wilson, Casey A. ; Lominac, Kevin D. ; Szumlinski, Karen K. ; Miller, Baily W. ; Szumlinski, Karen K ; Wilson, Casey A ; Renton, Rachel M ; Lominac, Kevin D ; Renton, Rachel M.

Globally, phenylpropanolamine (PPA) is a prevalent primary active ingredient in over-the-counter cough and cold, as well as weight-loss medications. Previously, we showed that a sensitization of cocaine-induced glutamate release within the nucleus accumbens (NAC) and the expression of cocaine-conditioned reward is not apparent in adult mice with a prior history of repeated PPA exposure during adolescence. As NAC glutamate is a purported driver of cocaine reward and reinforcement, the present study employed in vivo microdialysis and immunoblotting approaches to inform as to the receptor and transporter anomalies that might underpin the disrupted glutamate response to cocaine in adolescent PPA-exposed mice. For this, male and female C57BL/6J mice were pretreated, once daily, with either 0 or 40mg/kg PPA during post-natal days 35-44. Adolescent PPA pretreatment significantly altered the expression of mGlu2/3 and α2 receptors in the NAC, with less robust changes detected for EAAT2, D2 receptors, DAT and NET. However, we detected no overt change in the capacity of these receptors or transporters to affect extracellular glutamate levels in adolescent PPA-pretreated mice. The present findings contrast with the pronounced changes in the capacity of mGlu2/3 receptors, EAAT, DAT and NET to regulate NAC extracellular glutamate reported previously for juvenile PPA-pretreated mice, indicating further that the long-term biochemical consequences of PPA depend on the critical period of neurodevelopment during which an individual is PPA-exposed, although the specific biomolecular changes underpinning the cocaine phenotype produced by adolescent PPA remain to be elucidated.

100 Deals associated with Pipemidic Acid Hydrate

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KEGG	Wiki	ATC	Drug Bank
D01531	Pipemidic Acid Hydrate	J01MB04	DB13823

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Infections	CN	Jiangsu Nhwa Pharmaceutical Co., Ltd.	01 Jan 1984
Bacterial Infections	CN	Hunan Xiangquan Pharmaceutical Co., Ltd.	01 Jan 1984
Bacterial Infections	CN	Haerbin Taihua Pharmaceutical Co. Ltd.	01 Jan 1984
Urinary Tract Infections	CN	Hunan Xiangquan Pharmaceutical Co., Ltd.	01 Jan 1984
Urinary Tract Infections	CN	Jiangsu Nhwa Pharmaceutical Co., Ltd.	01 Jan 1984
Urinary Tract Infections	CN	Haerbin Taihua Pharmaceutical Co. Ltd.	01 Jan 1984
Cystitis	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Enteritis	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Otitis Media	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Prostatitis	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Pyelonephritis	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978
Sinusitis	JP	Nichi-Iko Pharmaceutical Co., Ltd.	01 Aug 1978

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