OBJECTIVETo evaluate the effect of Taohong Siwu Tang and its fractions on hotplate-induced pain in mice, acetic acid-induced writhing response, dysmenorrheal model and isolated uterine contraction in vitro in mice, and discuss material basis of effect sites.METHODThe samples of fractions were prepared by macroporous adsorptive resins (TH-1-TH-15). In the whole animal experiment, the hotplate-induced pain mice model was established to observe the effect of the samples on pain threshold in mice; the acetic acid-induced writhing response mice model was built to observe the effect of the samples on the writhing response in mice; the mice dysmenorrheal model was established to observe the effect of the samples on the writhing response, and calcium ion (Ca2+) and nitric oxide (NO) levels in uterine tissue of mice. In the isolated uterus contraction experiment, the oxytocin-induced isolated uterus contraction mice model was established to observe the effect of the samples on the isolated uterus contraction index. HPLC-DAD method was adopted for the content determination of effect sites.RESULTAccording to the evaluation of the integration geological effect, beside TH-2 and TH-4, other three active fractions (TH-9, TH-10 and TH-11) extracted from Taohong Siwu Tang are the main effect sites. Their chemical components were analyzed and identified as monoterpene glycosides, phthalides, organic acids, etc.CONCLUSIONThe effect sites of Taohong Siwu Tang on dysmenorrhea are TH-9, TH-10 and TH-11, which are 30% - 50% active fractions obtained from water-soluble small-molecular fractions by gradient elution using ethanol through macroporous absorption resin. Compared with TH-10 and TH-11, TH-9 shows stronger effect, which may be related to the type and content of chemical components it contains.

01 Dec 1975·Arkhiv anatomii, gistologii i embriologii

[X-ray anatomy of the abdominal aorta and its branches according to angiographic findings in living subjects].

Article

Author: Shendrik, Iu G

1. In the direct aortogram the shade of the abdominal aorta is projected into the left half of the vertebrum bodies from Th - 12 to L - 4. 2. The length of the abdominal aorta changes with age from 172,1 mm (in the age up to 40 years) to 203,7 mm (in 71-75 years) independent of the sex and is equal to 177,1-2,8 mm (sigma=21,8 mm). 3. The caliber of the abdominal aorta becomes narrower in the caudal direction, being most narrow between levels Th - 12, L - 1, and L - 2. Independent of the sex, the aorta caliber increases with age at the level of all lumbar vertebra. The difference in the caliber between cranial and caudal parts of the aorta increases with age from 6,7 mm (in the age of 40) up to 11,7 mm (in the age of 60-70). Mean values of the caliber at the level Th - 11 are equal to 26,9-0,8 mm (sigma=5,33 mm) and at the level L - 4 are equal to 18,9-0,3 mm (sigma = 2,9 mm). 4. The course of the abdominal aorta is directed downwards and to the middle. With age the aorta makes an arc-shaped bend to the left first at the level Th - 12, then L - 1, and in senile age at the level L - 2. 5. Independent of age and sex of examined persons the skeletotopical zones of orifices of the main visceral and paramural arteries were established which can significantly facilitate their selective angiography.

International Journal of Molecular SciencesQ2 · BIOLOGY

The Chitinolytic Activities of Streptomyces sp. TH-11

Q2 · BIOLOGY

ArticleOA

Author: Lin, Chung-Sheng ; Hoang, Kim-Chi ; Lai, Tzu-Hsuan ; Chen, Ying-Tsong ; Liau, Chun-Yi

Chitin is an abundant biopolymer composed of units of N-acetyl-D-glucosamine linked by b-1,4 glycosidic bonds. Chitin is the main component of the shells of mollusks, the cell wall of fungi and yeast and of the exoskeleton of crustaceans and insects. The degradation of chitin is catalyzed by chitinases that occur in a wide range of organisms. Among them, the chitinases from microorganisms are extremely important for the degradation and recycling of the carbon and nitrogen trapped in the large amount of insoluble chitin in nature. Streptomyces sp. TH-11 was isolated from the sediment of the Tou-Chien River, Taiwan. The chitinolytic enzyme activities were detected using a rapid in-gel detection method from the cell-free preparation of the culture medium of TH-11. The chitinolytic enzyme activity during prolonged liquid culturing was also analyzed by direct measurement of the chitin consumption. Decomposition of the exoskeleton of shrimps was demonstrated using electron microscopy and atomic force microscopy.

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Indication	Highest Phase	Country/Location	Organization	Date
Glioma	Preclinical	CN	Jinan Taihe Pharmaceutical Technology Co., Ltd.	08 Mar 2023

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