Delving into the Latest Updates on Artilide Fumarate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Artilide fumarate (USAN)

Target-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Arrhythmias, Cardiac

Originator Organization

Pfizer Inc.

Active Organization-

Inactive Organization

Pfizer Inc.

Pharmacia Corp.

Drug Highest PhaseDiscontinuedPhase 1

First Approval Date-

Regulation-

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Structure

Molecular FormulaC23H38N2O7S

InChIKeyHKBHZIDPRAWQFU-UHFFFAOYSA-N

CAS Registry133267-20-6

Ibutilide fumarate and artilide fumarate, new drugs for the treatment of cardiac arrhythmias, each contain a stereogenic center bearing a secondary alcohol group. Reversed-phase achiral-chiral column-switching HPLC separations of the enantiomers of each compound were developed and validated for quantitation in plasma and other biofluids. The key component of the method was derivatization with 1-naphthyl isocyanate, which enhanced the sensitivity of fluorescence detection and enabled the enantiomers to be separated on a Pirkle column (covalent 3,5-dinitrobenzoyl-D-phenylglycine stationary phase). The lower limit of quantitation of ibutilide fumarate was typically 0.1 ng/ml or less of each enantiomer in 1 ml of plasma. Two of the special features of the column-switching system included operation with two samples in the system at one time, which reduced analysis time to 16 min/sample for ibutilide and 19 min/sample for artilide, and a relay-operated switching of detector outputs, which allowed achiral and chiral column chromatographic data to be gathered from two detectors into a single data acquisition channel.

100 Deals associated with Artilide Fumarate

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External Link

KEGG	Wiki	ATC	Drug Bank
D02992	-	-	-

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Arrhythmias, Cardiac	Phase 1	-	Pfizer Inc.	-
Arrhythmias, Cardiac	Phase 1	-	Pfizer Inc.	-
Arrhythmias, Cardiac	Phase 1	US	Pharmacia Corp.	-
Arrhythmias, Cardiac	Phase 1	US	Pharmacia Corp.	-