A double-blind, randomized, placebo-controlled, clinical trial of neoadjuvant chemotherapy combined with WTPA for HER-2 negative locally advanced breast cancer

Start Date01 Mar 2010

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100 Clinical Results associated with Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

100 Translational Medicine associated with Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

100 Patents (Medical) associated with Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

Literatures (Medical) associated with Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

Frontiers in ImmunologyQ2 · MEDICINE

IL-17A Can Promote Propionibacterium acnes-Induced Sarcoidosis-Like Granulomatosis in Mice

Q2 · MEDICINE

ArticleOA

Author: Zhao, Mengmeng ; Weng, Dong ; Chen, Tao ; Zhou, Nianyu ; Zhang, Yuan ; Tang, Danli ; Zhou, Ying ; Lu, Liqin ; Yin, Chengsheng ; Li, Qiuhong ; Li, Huiping ; Song, Jiacui

The etiology of sarcoidosis is unknown. In this study, Propionibacterium acnes (PA) was used to induce sarcoidosis-like granulomatous inflammation in a mouse model. Wild-Type (WT) C57BL/6 mice were divided into three groups: (1) WT-PA group; (2) WT-PA + Incomplete Freund's Adjuvant (IFA) group; and (3) WT-PBS group. Loose granuloma formation was observed in the lungs on day 56 in the WT-PA and WT-PA + IFA groups. The proportions of peripheral Th17 cells in the WT-PA (p = 0.0004) and WT-PA + IFA groups (p = 0.0005) were significantly higher than that in the WT-PBS group. The proportions of peripheral Treg cells in the WT-PA (p < 0.0001) and WT-PA + IFA groups (p < 0.0001) were lower than that in the WT-PBS group. Then, to explore the mechanism of IL-17, Wild-Type (WT) C57BL/6 mice were divided into three groups: (1) WT-PBS group (2) WT-PA group; (3) WT-PA + mouse IL-17A neutralizing antibody (IL-17Ab) group. IL-17A gene knockout mice (KO) were divided into two groups: (1) KO -PA group; (2) KO-PBS group. The KO-PA and WT-PA + IL-17Ab groups showed reduced inflammation and no loose granuloma formation on day 56. As compared to the WT-PA group, the ratio of peripheral Th17 in the KO-PA (p < 0.0001) and WT-PA + IL-17Ab groups (p < 0.0001) decreased, while the ratio of peripheral Treg in the KO-PA (p < 0.0001) and WT-PA + IL-17Ab (p = 0.0069) groups increased on day 56. Hence, PA can be used to establish a mouse model of sarcoidosis-like granuloma. IL-17A plays an important role in experimental sarcoidosis-like granuloma formation.

100 Deals associated with Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

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Indication	Country/Location	Organization	Date
Bacterial Infections	China	Beijing Wanter Bio-Pharmaceutical Co., Ltd.	15 Apr 2004
Neoplasms	China	Beijing Wanter Bio-Pharmaceutical Co., Ltd.	15 Apr 2004

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ERS2020	Not Applicable	Rhinovirus infection \| Bronchogenic Carcinoma	-	Pseudomonas aeruginosa	gmwfrhispp(ayrhqhhorr) = umufxzyrlt mfmgliwoum (jbhtmijmzd )	-	07 Sep 2020
				Pseudomonas aeruginosa	gmwfrhispp(ayrhqhhorr) = xfovjzjcrb mfmgliwoum (jbhtmijmzd )
ERS2017	Not Applicable	Bronchiectasis Pseudomonas aeruginosa	2,596	Pseudomonas aeruginosa	czqxbiwrwc(umhvomkdxn) = qfwcediczu aiituqecmb (umgvdflgzl )	-	01 Sep 2017
ARVO2016	Not Applicable	Corneal epithelial defect	-	Pseudomonas aeruginosa (HeLa cells)	uqonklyreg(oogfbfoicw) = fupdtfnmyb jdrfwmcdql (xsapeuatrv )	-	01 May 2016
				Pseudomonas aeruginosa (Human telomerase-immortalized corneal epithelial cells)	uqonklyreg(oogfbfoicw) = dqgftetfel jdrfwmcdql (xsapeuatrv )

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Pseudomonas aeruginosa(Beijing Wante'Er Biological Pharmaceutical Co Ltd)

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