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Last update 31 May 2025
TOP-1288
Last update 31 May 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms TOP 1288 |
Target |
Action inhibitors |
Mechanism SRC inhibitors(Tyrosine-protein kinase SRC inhibitors), Syk inhibitors(Spleen tyrosine kinase inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhasePendingPhase 2 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC43H49N7O9S |
InChIKeyFWXVGKSWZJEPQI-UHFFFAOYSA-N |
CAS Registry1630202-02-6 |
Related
3
Clinical Trials associated with TOP-1288NCT03071081
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of TOP1288 Oral Single Ascending and Multiple Doses in Healthy Volunteers
NCT02888379
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Symptomatic Ulcerative Colitis Patients With Moderate to Severe Disease Activity
NCT02463045
A Phase I Study to Evaluate the Safety/Tolerability and Pharmacokinetics of TOP1288 Rectal Single and Multiple Ascending Doses in Healthy Subjects and Multiple Doses in Subjects With Ulcerative Colitis
100 Clinical Results associated with TOP-1288
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100 Translational Medicine associated with TOP-1288
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100 Patents (Medical) associated with TOP-1288
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100 Deals associated with TOP-1288
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Colitis, Ulcerative | Phase 2 | Bulgaria | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Czechia | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Hungary | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Latvia | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Lithuania | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Poland | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | Ukraine | 01 Sep 2016 | |
| Colitis, Ulcerative | Phase 2 | United Kingdom | 01 Sep 2016 |
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