Last update 21 Nov 2024

TOP-1288

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
SRC x Syk x p38α
Mechanism
SRC inhibitors(Tyrosine-protein kinase SRC inhibitors), Syk inhibitors(Spleen tyrosine kinase inhibitors), p38α inhibitors(P38 α mitogen-activated protein kinase inhibitors)
Therapeutic Areas
Digestive System Disorders
Active Indication-
Inactive Indication
Colitis, Ulcerative
Originator Organization
TopiVert Ltd.TopiVert Ltd.
Active Organization-
Inactive Organization
Topivert Pharma Ltd.TopiVert Ltd.TopiVert Ltd.
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC43H49N7O9S
InChIKeyFWXVGKSWZJEPQI-UHFFFAOYSA-N
CAS Registry1630202-02-6

Related

6
Clinical Trials associated with TOP-1288
NCT03071081 / CompletedPhase 1
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of TOP1288 Oral Single Ascending and Multiple Doses in Healthy Volunteers
NCT02888379 / CompletedPhase 2
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Symptomatic Ulcerative Colitis Patients With Moderate to Severe Disease Activity
EUCTR2016-000390-20-CZ / Not yet recruitingPhase 2
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Symptomatic Ulcerative Colitis Patients with Moderate to Severe Disease Activity
100 Clinical Results associated with TOP-1288
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100 Translational Medicine associated with TOP-1288
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100 Patents (Medical) associated with TOP-1288
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100 Deals associated with TOP-1288
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External Link

KEGGWikiATCDrug Bank
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DB14839

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colitis, UlcerativePhase 2
GB
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
UA
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
HU
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
UA
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
HU
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
LT
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
CZ
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
LT
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
GB
TopiVert Ltd.TopiVert Ltd.
-
Colitis, UlcerativePhase 2
CZ
TopiVert Ltd.TopiVert Ltd.
-
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Approval

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Regulation

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