Comparative evaluation of different CMR pulse-sequences with respect to their practicability and diagnostic performance in diagnosing the inflamed myocardium in patients with acute myocardial infarction based on the detection of macrophages in the infarcted myocardium using Resovist® and FerahemeTM

Start Date16 Mar 2009

Sponsor / Collaborator-

NCT00372281 / Unknown statusPhase 3IIT

Comparison of Cliavist Enhancement in Infectious and Degenerative Diseases of the Spine

USPIO contrast enhancement results from intracellular trapping of the iron particles in reactive cells, especially macrophages. 17FDG-PET studies have demonstrated that macrophages are present in spine infectious diseases but are absent in spine degenerative diseases. The aim of this work is to compare the enhancement induced by CLIAVIST in both diseases. The absence of macrophages in degenerative lesions should help to differentiate them from infectious lesions, who should present contrast enhancement in relation to the presence of macrophages.

Start Date01 Mar 2007

Sponsor / Collaborator

Les Hopitaux Universitaires de Strasbourg

100 Clinical Results associated with Ferucarbotran

100 Translational Medicine associated with Ferucarbotran

100 Patents (Medical) associated with Ferucarbotran

317

Literatures (Medical) associated with Ferucarbotran

01 Oct 2024·Investigative Radiology

Pathophysiologic Mapping of Chronic Liver Diseases With Longitudinal Multiparametric MRI in Animal Models

Article

Author: von Stillfried, Saskia ; Lemainque, Teresa ; Koletnik, Susanne ; Boor, Peter ; Kiessling, Fabian ; Schulz, Volkmar ; Talbot, Steven R. ; Lederle, Wiltrud ; Talbot, Steven R ; Klinkhammer, Barbara ; Baskaya, Ferhan

ObjectivesChronic liver diseases (CLDs) have diverse etiologies. To better classify CLDs, we explored the ability of longitudinal multiparametric MRI (magnetic resonance imaging) in depicting alterations in liver morphology, inflammation, and hepatocyte and macrophage activity in murine high-fat diet (HFD)– and carbon tetrachloride (CCl4)–induced CLD models.Materials and MethodsMice were either untreated, fed an HFD for 24 weeks, or injected with CCl4for 8 weeks. Longitudinal multiparametric MRI was performed every 4 weeks using a 7 T MRI scanner, including T1/T2 relaxometry, morphological T1/T2-weighted imaging, and fat-selective imaging. Diffusion-weighted imaging was applied to assess fibrotic remodeling and T1-weighted and T2*-weighted dynamic contrast-enhanced MRI and dynamic susceptibility contrast MRI using gadoxetic acid and ferucarbotran to target hepatocytes and the mononuclear phagocyte system, respectively. Imaging data were associated with histopathological and serological analyses. Principal component analysis and clustering were used to reveal underlying disease patterns.ResultsThe MRI parameters significantly correlated with histologically confirmed steatosis, fibrosis, and liver damage, with varying importance. No single MRI parameter exclusively correlated with 1 pathophysiological feature, underscoring the necessity for using parameter patterns. Clustering revealed early-stage, model-specific patterns. Although the HFD model exhibited pronounced liver fat content and fibrosis, the CCl4model indicated reduced liver fat content and impaired hepatocyte and macrophage function. In both models, MRI biomarkers of inflammation were elevated.ConclusionsMultiparametric MRI patterns can be assigned to pathophysiological processes and used for murine CLD classification and progression tracking. These MRI biomarker patterns can directly be explored clinically to improve early CLD detection and differentiation and to refine treatments.

07 Jul 2024·Physics in Medicine & Biology

Characterization of the clinically approved MRI tracer resotran for magnetic particle imaging in a comparison study

Article

Author: Graeser, Matthias ; Vogel, Patrick ; Mohn, Fabian ; Ahlborg, Mandy ; Wegner, Franz ; Knopp, Tobias ; Weimer, Agnes ; Thieben, Florian ; Scheffler, Konrad ; Ackers, Justin

AbstractObjective. The availability of magnetic nanoparticles (MNPs) with medical approval for human intervention is fundamental to the clinical translation of magnetic particle imaging (MPI). In this work, we thoroughly evaluate and compare the magnetic properties of an magnetic resonance imaging (MRI) approved tracer to validate its performance for MPI in future human trials. Approach. We analyze whether the recently approved MRI tracer Resotran is suitable for MPI. In addition, we compare Resotran with the previously approved and extensively studied tracer Resovist, with Ferrotran, which is currently in a clinical phase III study, and with the tailored MPI tracer Perimag. Main results. Initial magnetic particle spectroscopy (MPS) measurements indicate that Resotran exhibits performance characteristics akin to Resovist, but below Perimag. We provide data on four different tracers using dynamic light scattering, transmission electron microscopy, vibrating sample magnetometry measurements, MPS to derive hysteresis, point spread functions, and a serial dilution, as well as system matrix based MPI measurements on a preclinical scanner (Bruker 25/20 FF), including reconstructed images. Significance. Numerous approved MNPs used as tracers in MRI lack the necessary magnetic properties essential for robust signal generation in MPI. The process of obtaining medical approval for dedicated MPI tracers optimized for signal performance is an arduous and costly endeavor, often only justifiable for companies with a well-defined clinical business case. Resotran is an approved tracer that has become available in Europe for MRI. In this work, we study the eligibility of Resotran for MPI in an effort to pave the way for human MPI trials.

01 Oct 2023·Colloids and Surfaces B: Biointerfaces

Fabrication of water-dispersible and cell-stimulating calcium phosphate nanoparticles immobilizing basic fibroblast growth factor

Article

Author: Nakamura, Maki ; Oyane, Ayako ; Araki, Hiroko ; Tsurushima, Hideo

Basic fibroblast growth factor (bFGF) is a therapeutic protein that can enhance angiogenesis, wound healing, and tissue regeneration; however, it is extremely unstable even under a normal physiological environment. Biocompatible calcium phosphate (CaP) nanoparticles (NPs) co-immobilizing bFGF, heparin, and ferucarbotran would be useful as a multifunctional delivery carrier of bFGF. In this study, such NPs were successfully fabricated by a coprecipitation process, using a labile supersaturated CaP solution containing bFGF, heparin, and ferucarbotran. The NPs showed relatively high negative zeta potential (-12 mV) because of the negatively charged heparin, which enabled their stable dispersion in water. The hydrodynamic diameter of the NPs was around 200 nm. Immunoreactive bFGF was released from the NPs in an acellular medium dose-dependently. The NPs promoted proliferation of baby hamster kidney fibroblasts (BHK-21 cells) and mouse osteoblastic MC3T3-E1 cells at a certain dose range, although they inhibited proliferation of rat pheochromocytoma (PC-12) cells. These results demonstrated that the effect of the NPs on cell proliferation was dependent on the cell type and dose, the details of which should be investigated in a future study.

News (Medical) associated with Ferucarbotran

17 Apr 2024

·www.prnewswire.com

Sanochemia: New contrast agent aims to detect the smallest lymphatic metastases in prostate cancer

NEUFELD, Austria, April 17, 2024 /PRNewswire/ -- Sanochemia Pharmazeutika secures exclusive licensing rights to a new MRI contrast agent based on ferumoxtran, that is in an advanced pivotal trial in clinical phase III and may be used to detect the smallest lymph node metastases in prostate cancer patients. The product is already deployed in the Netherlands within an authorized Named-Patient-Use-Program (Artsenverklaring). Continue Reading Official signing of license deal with Thomas Erkinger and Jürgen Feuerstein The agreement with SPL Medical (Nijmegen, Netherlands) grants Sanochemia exclusive worldwide rights for parts of the manufacture and global distribution of an MRI contrast agent based on ferumoxtran with the exception of the DACH region. The product, which is currently under development in late phase III at several renowned European clinics, shall carry the registered trademark Ferrotran®. Ferrotran® contains iron-based superparamagnetic nanoparticles and is intended to be used to detect even the smallest lymph node metastases in prostate cancer patients. Research is being conducted into the possible use for other types of cancer. Ferrotran® will be the second iron-containing product in Sanochemia's gadolinium-free MRI product range. Only recently, an agreement with b.e.imaging (Baden-Baden, Germany) was announced on the MRI contrast agent Resotran® (ferucarbotran) for the detection of focal liver lesions in adults. "The two agreements mark the start of a new product line," said Sanochemia Managing Director Thomas Erkinger. "We are striving to play a pioneering role in the field of gadolinium-free MRI contrast agents. Innovative specialties optimally complement our classic product line in diagnostic imaging". Both products are based on iron-oxide nanoparticles (USPIO/SPIO: Ultrasmall / Small Superparamagnetic Iron Oxide) and expand the diagnostic options within radiology. Dr. Jürgen Feuerstein, CEO of licensor SPL Medical: "We are gaining access to the worldwide market of medical imaging via the extensive marketing network of Sanochemia. Within an authorized named-patient-use-program, more than 700 prostate cancer patients have already been diagnosed in Nijmegen with ferumoxtran in the Netherlands, enabling them to receive earlier and more specific treatment and a significantly higher chance of recovery. The earlier affected lymph nodes are detected, the better the chances of recovery with targeted, less invasive treatment." Sanochemia Pharmazeutika Sanochemia is a leading supplier of pharmaceuticals for radiological applications in the center of Europe. In addition to classic contrast agents, the company focuses on organ-specific and gadolinium-free specialty products. The company's imaging agents are used by doctors and hospitals in over 50 countries worldwide for diagnostic imaging in MR and CT procedures. At the Austrian production site, more than 200 employees ensure that drug products (FDF) and active pharmaceutical ingredients (APIs) are manufactured to the highest pharmaceutical quality standards. Photo: Logo: SOURCE Sanochemia Pharmazeutika

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100 Deals associated with Ferucarbotran

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Contrast agents	JP	Kyowa Criticare Co. Ltd.	08 Oct 2002

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Indication	Highest Phase	Country/Location	Organization	Date
Liver Cancer	Preclinical	US	Bayer HealthCare Pharmaceuticals, Inc.	-

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