Delving into the Latest Updates on A-42867 with Synapse

Overview

Basic Info

Drug Type

Synthetic peptide

Synonyms

Target-

Action

inhibitors

Mechanism

Cell wall inhibitors

Therapeutic Areas

Infectious Diseases

Active Indication-

Inactive Indication

Bacterial Infections

Originator Organization

Biosearch Italia SpA

Active Organization-

Inactive Organization

Biosearch Italia SpA

License Organization-

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

A42867 is a new glycopeptide antibiotic of the ristocetin-vancomycin class active against aerobic and anaerobic Gram-positive bacteria. A42867 is produced by a strain of Nocardia nov. sp. ATCC 53492. A42867 was isolated during a screening program aimed at the discovery of new members of this glycopeptide class of antibiotics, by affinity chromatography based on an acyl-D-alanyl-D-alanine probe. The structure of A42867 was elucidated by fast atom bombardment MS, high field 2D 1H NMR spectroscopy, and HPLC analysis of the hydrolyzed carbohydrates. A42867 differs from vancomycin in the sugar portion and in the presence of only one chlorine atom in the peptide core. Its biological activity on Gram-positive aerobic and anaerobic bacteria is similar to that of other antibiotics of this group.

100 Deals associated with A-42867

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Infections	Preclinical	Italy	Biosearch Italia SpA	-

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Clinical Result

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Deal

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Approval

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Biosimilar

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