Delving into the Latest Updates on Bismuth Subnitrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Bismuth hydroxide nitrate oxide, Bismuth nitrate, basic, Bismuth subnitrate (JP17/USP)

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Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Diarrhea

Inactive Indication-

Originator Organization

SIOE Pharmaceutical Co., Ltd.

Active Organization

SIOE Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (01 Mar 1952),

Diarrhea

Regulation-

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The aim of this study is to evaluate the efficacy and safety of a quadruple therapy consisting of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate for the first phase eradication of Helicobacter pylori. Assuming that the quadruple therapy of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate is no less effective than the bismuth containing quadruple therapy of amoxicillin and clarithromycin. Patients diagnosed with Helicobacter pylori infection will be randomly assigned to one of the aforementioned treatments. During the 6-week follow-up, urea breath test, rapid urease test, or Helicobacter pylori fecal antigen test will be performed to confirm eradication.
The aim of this study is to evaluate the efficacy and safety of a quadruple therapy consisting of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate for the first phase eradication of Helicobacter pylori. Assuming that the quadruple therapy of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate is no less effective than the bismuth containing quadruple therapy of amoxicillin and clarithromycin. Patients diagnosed with Helicobacter pylori infection will be randomly assigned to one of the aforementioned treatments. During the 6-week follow-up, urea breath test, rapid urease test, or Helicobacter pylori fecal antigen test will be performed to confirm eradication.

Start Date20 Nov 2023

Sponsor / Collaborator

Xijing Hospital

IRCT201406141155N19 / CompletedPhase 3IIT

The comparison between effects and side effects of seven days or ten days quadruple therapy regimens (Bismuth sub citrate, Levofloxacin, Amoxicillin and Pantazole) in eradication of H.pylori infection.

Start Date15 Jul 2015

Sponsor / Collaborator-

IRCT201103011155N11 / CompletedPhase 2IIT

Comparing the five-drug regimen ( Bismuth sub-citrate , Omeprazole , Amoxicillin , Clarithromycin , Tinidazole ) and ( Bismuth sub citrate , Omeprazole , Tetracycline , Metronidazole , Ofloxacin ) on the eradication rate of Helicobacter pylori infection in non responder dyspeptic patients

Start Date09 Feb 2011

Sponsor / Collaborator-

100 Clinical Results associated with Bismuth Subnitrate

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100 Translational Medicine associated with Bismuth Subnitrate

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100 Patents (Medical) associated with Bismuth Subnitrate

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147

Literatures (Medical) associated with Bismuth Subnitrate

15 Oct 2024·ACS Omega

Recyclability of Zinc Palmitate-Based Composites in Fatty Acid Methyl Ester Production from Oil Feedstocks at Varied Acidity

Article

Author: Woranuch, Warisara ; Smith, Siwaporn Meejoo ; Posa, Charoen ; Chaiseeda, Kittichai ; Pratumyot, Kornkanya ; Sungayuth, Nongnuch ; Junpuek, Palmpapat

Zinc hydroxide nitrate (Zn5) is one of the layered metal hydroxide materials, which has been extensively reported as an effective bifunctional catalyst for biodiesel production from acidic oils. This report gives a comprehensive summary of the reactivity of Zn5 in the methanolysis of various oil feedstocks, plant oils, free fatty acids, and other acidic oils. Notably, as evidenced by this work, Zn5 is highly effective in converting acidic oils [palmitic acid/palm oil (PO)] to fatty acid methyl ester (FAME or biodiesel) at high yields ranging from 80 to 95%, withstanding acid content up to 10% without soap formation. The high FAME yields result from complex methanolysis and hydrolysis processes, e.g., transesterification of triglycerides in the PO, esterification of palmitic acid, and hydrolysis of the triglycerides. Despite this, Zn5 is nonrecyclable because it is unstable in the reaction media and transforms into zinc hydroxide nitrate/zinc palmitate (Zn5/ZnP) composites. The Zn5/ZnP composites were suitable for use in FAME production from PO at 100 °C for 2 h by using a methanol-to-oil molar ratio of 30:1, yielding high FAME yields of 97 and 70.7% in the first and fourth cycles, respectively. This study added better insight into how to effectively produce FAME from oil feedstocks of varying acidity by using zinc layered hydroxide- or zinc carboxylate-based materials.

01 Jun 2022·Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere

Neue Arzneimittel für Großtiere 2021

Article

Author: Emmerich, Ilka Ute

23 Feb 2022·Microbiology SpectrumQ2 · BIOLOGY

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria

Q2 · BIOLOGY

Article

Author: Tong, Ziwen ; Liu, Yuan ; Shi, Jingru ; Wang, Zhiqiang ; Deng, Tian ; Jia, Yuqian

Recently, high-level tigecycline resistance mediated by tet (X4) and its variants represents a serious challenge for global public health. Antibiotic adjuvant strategy that enhances the activity of the existing antibiotics by using nonantibiotic drugs offers a distinct approach to combat the antibiotic resistance crisis. In this study, we found that bismuth drugs involve bismuth nitrate, a compound previously approved for treatment of stomach-associated diseases, remarkably potentiates tigecycline activity against tet (X)-positive bacteria.

100 Deals associated with Bismuth Subnitrate

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