Delving into the Latest Updates on Cathelicidin-BF with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

Mechanism

CAMP modulators(Cathelicidin antimicrobial peptide modulators), CAMP stimulants(Cathelicidin antimicrobial peptide stimulants)

Therapeutic Areas

Infectious DiseasesUrogenital Diseases

Active Indication

Bacterial VaginosisGram-Negative Bacterial Infections

Inactive Indication-

Originator Organization

Suzhou Kanger Biomedical Co. Ltd.

Active Organization

Chinese Academy of Sciences

China Pharmaceutical University

Suzhou Kanger Biomedical Co. Ltd.

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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Structure/Sequence

Sequence Code 32108

Primary objective: To evaluate the safety and tolerability of a single dose of Bungarus antimicrobial peptide vaginal effervescent tablets in healthy adult female subjects. Secondary objective: To evaluate the preliminary human pharmacokinetic characteristics of a single dose of Bungarus antimicrobial peptide vaginal effervescent tablets in healthy adult female subjects.

Start Date03 Nov 2021

Sponsor / Collaborator

Suzhou Kanger Biomedical Co. Ltd.

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100 Clinical Results associated with Cathelicidin-BF

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100 Translational Medicine associated with Cathelicidin-BF

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100 Patents (Medical) associated with Cathelicidin-BF

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248

Literatures (Medical) associated with Cathelicidin-BF

01 Mar 2025·Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

Antimicrobial activity and immunomodulation of four novel cathelicidin genes isolated from the tiger frog Hoplobatrachus rugulosus

Article

Author: Bo, Jun ; Huang, Wenshu ; Huang, Yixin ; Huang, Danni ; Gao, Fulong ; Zheng, Ronghui ; Wang, Kejian ; Fang, Chao

Cathelicidin is a family of antimicrobial peptides in vertebrates that plays an important role in resistance and immunization against pathogenic microorganisms. In the present study, the full-length cDNA sequences of four novel cathelicidins (cathelicidin-1 to cathelicidin-4) in the tiger frog Hoplobatrachus rugulosus, encoding 153, 188, 132, and 160 amino acids, respectively, were firstly cloned by rapid amplification of the cDNA ends (RACE) technique. Sequence comparison and phylogenetic tree analysis indicated that the structures of the four cathelicidins are highly diverse. Afterwards, the tissue distribution profiles and antimicrobial patterns of cathelicidins in H. rugulosus were determined by real-time PCR. The four cathelicidins showed tissue-specific distribution patterns in the healthy frogs, and the transcriptional levels of cathelicidins exhibited a tissue- and time-dependency profile in the frogs challenged with pathogenic bacteria Aeromonas hydrophila for 72 h. The synthetic peptides of cathelicidin-1 and cathelicidin-2 exhibited broad-spectrum in vitro antimicrobial activity, and cathelicidins exerted antimicrobial activities through excessive induction of reactive oxygen species and direct disruption of the microbial membrane structure. In addition, the intraperitoneal injection of cathelicidin proteins significantly increased the marine medaka Oryzias melastigma resistance to bacterial challenges. The existence of multiple cathelicidins, their distinct tissue distribution patterns, and the inducible expression profiles suggest a sophisticated, highly redundant, and multilevel network of antimicrobial defense mechanisms in tiger frogs. This study provides evidence that cathelicidins have antimicrobial and immunomodulatory activities, and cathelicidins derived from H. rugulosus have potential therapeutic applications against pathogenic infections in aquaculture.

01 Feb 2025·International Journal of Biological Macromolecules

The novel cathelicidin-DM antimicrobial peptide conjugated carbomer and thermosensitive chitosan hydrogel speeds up wound-healing in both non-infected and S. aureus-infected wounds

Article

Author: Shi, Yaoqiang ; Han, Qinqin ; Zhang, Jinyang ; Wang, Guixi ; Song, Yuzhu ; Huang, Yafei ; Li, Chao

The emergence of chronic wound infections and bacterial resistance presents substantial clinical challenges that impact millions worldwide. Antimicrobial peptides (AMPs), recognized for their potent antimicrobial properties, are considered promising alternatives to conventional antibiotics in light of escalating drug resistance. In previous research, we isolated an AMP named cathelicidin-DM from Duttaphrynus melanostictus, which exhibited broad-spectrum efficacy against multidrug-resistant bacteria and demonstrated wound-healing capabilities. This peptide represents a novel therapeutic option for treating infected chronic wounds. However, AMPs are susceptible to degradation when applied in the treatment of wound infections, which may compromise their effectiveness. To further advance the application of cathelicidin-DM in wound healing, we developed cathelicidin-DM-carbomer and thermosensitive cathelicidin-DM-chitosan hydrogels. Our results indicated that cathelicidin-DM interacted with both carbomer and chitosan at the molecular level, adhering to the surface of the hydrogels, which exhibit a three-dimensional network structure and favorable rheological properties. Animal experiments demonstrated that these cathelicidin-DM hydrogels exhibited hemostatic capabilities and significantly enhance the healing of both infected and non-infected full-thickness skin wounds in mice when applied as wound dressings. In summary, cathelicidin-DM carbomer and cathelicidin-DM chitosan hydrogels represent a dual-functional materials with both antimicrobial and wound-healing properties, thereby demonstrating considerable potential for clinical application.

01 Jan 2025·Veterinary Immunology and Immunopathology

Cathelicidins in farm animals: Structural diversity, mechanisms of action, and therapeutic potential in the face of antimicrobial resistance

Review

Author: Ahlawat, Sonika ; Sharma, Upasna ; Sharma, Rekha ; Chhabra, Pooja ; Bagiyal, Meena ; Parsad, Ram ; Gera, Ritika ; Arora, Reena

Cathelicidins are a diverse family of antimicrobial peptides found across many vertebrate species, playing a pivotal role in the innate immune system. These peptides exhibit a variety of structural motifs, including α-helices, β-hairpins, and random coils, contributing to their broad-spectrum antimicrobial activity. The structural diversity of cathelicidins allows them to interact with a wide range of microbial targets, thereby enhancing their antimicrobial efficacy. Distinct species produce specific cathelicidins, each adapted to meet their unique immune requirements. Cathelicidins primarily function by disrupting microbial membranes, leading to cell lysis. Beyond their direct antimicrobial action, they possess immunomodulatory properties that bolster host defense mechanisms. These properties include promoting chemotaxis, enhancing phagocytosis, and inducing cytokine production, thereby modulating the host immune response. The therapeutic potential of cathelicidins is significant, especially in light of the growing challenge of antimicrobial resistance (AMR). As conventional antibiotics lose efficacy, cathelicidins emerge as promising alternatives due to their unique mechanisms of action and reduced likelihood of inducing resistance. Recent research underscores their potential in treating infections, inflammatory diseases, and even cancer. Advances in synthetic biology offer promising prospects for effective cathelicidin-based therapies in the future. This review summarizes the diversity, modes of action, and clinical prospects of cathelicidins specific to farm animals.

100 Deals associated with Cathelicidin-BF

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Vaginosis	Phase 1	CN	Suzhou Kanger Biomedical Co. Ltd.	03 Nov 2021
Bacterial Vaginosis	Phase 1	CN	China Pharmaceutical University	03 Nov 2021
Gram-Negative Bacterial Infections	Preclinical	CN	Chinese Academy of Sciences	16 Sep 2008