Delving into the Latest Updates on BIIB-095 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

BIIB 095

Target

Nav1.7

Action

blockers

Mechanism

Nav1.7 blockers(Sodium channel protein type IX alpha subunit blockers)

Therapeutic Areas

Nervous System DiseasesEndocrinology and Metabolic DiseaseOther Diseases

Active Indication-

Inactive Indication

Diabetic peripheral neuropathic painNeuralgia

Originator Organization

Biogen, Inc.

Active Organization-

Inactive Organization

Biogen, Inc.

License Organization-

Drug Highest PhaseDiscontinuedPhase 1

First Approval Date-

Regulation-

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Part A: Primary objective is to determine the effects of BIIB095 on nerve excitability in healthy participants. Secondary and exploratory objectives include determining the effects of BIIB095 on nerve excitability in diabetic polyneuropathy (DPN) and assessing the safety, tolerability and pharmacokinetics of BIIB095.
Part B (optional): Equivalent objectives are pursued for BIIB074.

Start Date30 Sep 2020

Sponsor / Collaborator

Biogen, Inc.

NCT03454126

/ CompletedPhase 1

A Phase 1, Randomized, Double-Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB095 in Healthy Subjects

The primary objective of the study is to evaluate the safety and tolerability of single- and multiple-ascending oral doses of BIIB095 in healthy participants. The secondary objectives are to characterize the single- and multiple-oral-dose PK of BIIB095 in healthy participants and to investigate the effect of food on the single-oral-dose PK of BIIB095 in healthy participants.

Start Date29 Mar 2018

Sponsor / Collaborator

Biogen, Inc.

100 Clinical Results associated with BIIB-095

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100 Translational Medicine associated with BIIB-095

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100 Patents (Medical) associated with BIIB-095

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100 Deals associated with BIIB-095

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