Last update 27 Sep 2025

BMS-986490

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
CEACAM5-TOPO1 ADC (Bristol Myers Squibb), BMS 986490, BMS986490
Target
CEACAM5 x Top I
Action
modulators, inhibitors
Mechanism
CEACAM5 modulators(Carcinoembryonic antigen related cell adhesion molecule 5 modulators), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid Neoplasm
Inactive Indication-
Originator Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Active Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with BMS-986490
NCT06730750
/ RecruitingPhase 1/2
A Phase 1/2a, Multicenter, Open-label, First in Human Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors
100 Clinical Results associated with BMS-986490
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100 Translational Medicine associated with BMS-986490
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100 Patents (Medical) associated with BMS-986490
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100 Deals associated with BMS-986490
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
United States
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
12 Feb 2025
Advanced Malignant Solid NeoplasmPhase 2
Australia
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
12 Feb 2025
Advanced Malignant Solid NeoplasmPhase 2
Canada
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
12 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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