Delving into the Latest Updates on Nigella sativa seed extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

Nigella sativa seeds extract containing ointment intervention

Target-

Mechanism-

Therapeutic Areas

Infectious DiseasesOtorhinolaryngologic DiseasesRespiratory Diseases

Active Indication

Chronic sinusitis

Inactive Indication

Arsenical keratosisCOVID-19Diabetes Mellitus+ [4]

Originator Organization-

Active Organization

Cairo University

Inactive Organization

Aga Khan UniversityHôpital Universitaire Sahloul

Bangabandhu Sheikh Mujib Medical University

+ [2]

Drug Highest PhaseClinical

First Approval Date-

Regulation-

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The world is currently facing a crisis because of this potentially fatal situation of the COVID-19 epidemic without proven efficacy for any drug treatment, while the vaccination is not yet.
This epidemic is caused by a new betacorona virus, now called SARS-CoV-2. The most common symptoms reported are fever, cough or chest tightness, and dyspnea. Most cases have a mild course

Start Date01 Mar 2021

Sponsor / Collaborator

Hôpital Universitaire Sahloul

NCT04686461 / Unknown statusNot ApplicableIIT

Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis

Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and after the intervention.

Start Date20 Oct 2019

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

100 Clinical Results associated with Nigella sativa seed extract

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100 Translational Medicine associated with Nigella sativa seed extract

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100 Patents (Medical) associated with Nigella sativa seed extract

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214

Literatures (Medical) associated with Nigella sativa seed extract

01 Oct 2024·Prostaglandins & Other Lipid Mediators

The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials

Review

Author: Jamali, Mehrdad ; Shakarami, Mehrnaz ; Pam, Pedram

This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of Nigella sativa (N. sativa) consumption on glycemic index in adults. A systematic literature search up to December 2023 was completed in PubMed, Scopus, and Web of Science, to identify eligible RCTs. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval. Finally, a total of 30 studies were found to be eligible for this meta-analysis. The pooled results using random effects model indicated that N. sativa supplementation significantly reduced FBS (SMD: -1.71; 95 % CI: -2.11, -1.31, p <0.001; I²= 92.7 %, p-heterogeneity <0.001) and HA1c levels (SMD: -2.16; 95 % CI: -3.04, -1.29, p <0.001; I²= 95.7 %, p-heterogeneity <0.001) but not effect on insulin (SMD = 0.48; 95 % CI: -0.53, 1.48, P = 0.353; I²= 96.1 %, p-heterogeneity <0.001), and HOMA-IR (SMD: -0.56; 95 % CI: -1.47, 0.35, p=0.229; I²= 95.0 %, p-heterogeneity <0.001).Overall, the evidence supports the consumption of N. sativa to reduce FBS and HA1c levels. Additional research, featuring extended durations and robust study designs, is necessary to determine the ideal dosage and duration of N. sativa supplementation for achieving a positive impact on glycemic markers.

01 Jul 2024·Heliyon

Manuka combinations with nigella sativa and hydroxyurea in treating iron overload of pediatric β-thalassemia major, randomized clinical trial

Article

Author: Elberry, Ahmed A ; Hussein, Raghda R S ; Abdelhalim, Shaimaa M ; Meabed, Mohamed Hussein ; Gamaleldin, Mohamed M ; Mahmoud Hussein, Ahmed F ; Abraham, Ivo L

Backgroundβ-thalassemia major is microcytic hypochromic anemia disorder inherited from parents, resulting from a mutation in the β-globin locus. As a result, a quantitative defective hemoglobin synthesis and relative excess in α-globin is occurred. As such, frequent blood transfusion is required, that leads to iron overload. Iron overload results in several pathological complications, including cell death, tissue injury, organ dysfunction, and liver fibrosis. The present study examined the effectiveness of nigella Sativa and manuka honey combination or manuka honey alone to the conventional therapy (Deferasirox + blood transfusion) used for preventing and managing iron overload in pediatric β-thalassemia major patients.MethodsOne hundred sixty-five patients participated in this randomized, double-blind, standard therapy-controlled, parallel-design multisite trial. The patients were randomly allocated into three groups, receiving either 500 mg nigella sativa oil combined with manuka honey lozenge (344 mg) daily or manuka honey alone plus the conventional therapy for ten treatment months. Ferritin level, serum iron, transferrin saturation, total iron binding capacity, alanine transaminase, and aspartate transaminase were determined at baseline and month 10.ResultsEventually, serum ferritin and iron were decreased significantly in the nigella sativa + manuka honey group as compared with the control group. Other clinical parameters were significantly impacted. The level of alanine transaminase and aspartate transaminase were significantly decreased in the nigella sativa plus manuka honey group compared with the control group.ConclusionResults showed that nigella sativa plus manuka honey was more effective than manuka alone or the conventional treatment alone in managing iron overload of β-thalassemia major patients.

01 Jun 2024·Clinical Nutrition ESPEN

Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials

Review

Author: Falahatzadeh, Maryam ; Vajdi, Mahdi ; Rounagh, Mahsa ; Hosseininejad-Mohebati, Ali ; Rostami, Reza Bijan ; Kavyani, Zeynab ; Musazadeh, Vali

BACKGROUND AND AIMSeveral experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.METHODSWe searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.RESULTSThe findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: -1.78; 95% CI: -2.20, -1.37, p < 0.001), triglycerides (TG) (SMD: -1.2725; 95% CI: -1.67, -0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: -2.45; 95% CI: -3.06, -1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).CONCLUSIONN. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.

100 Deals associated with Nigella sativa seed extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Discovery	PK	Sheikh Zayed Federal Postgraduate Medical Institute	05 Mar 2021
Arsenical keratosis	Discovery	BD	Bangabandhu Sheikh Mujib Medical University	20 Oct 2019
Dyslipidemias	Discovery	ID	University of Indonesia	01 Sep 2011
Diabetes Mellitus	Discovery	PK	Aga Khan University	01 Feb 2006
Hypercholesterolemia	Discovery	PK	Aga Khan University	01 Feb 2006
Hypertension	Discovery	PK	Aga Khan University	01 Feb 2006
Metabolic Syndrome	Discovery	PK	Aga Khan University	01 Feb 2006