Last update 08 Nov 2025

YH-42946

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
YH 42946, YH42946
Target
EGFR exon 20
Action
inhibitors
Mechanism
EGFR exon 20 inhibitors(EGFR exon 20 Mutation inhibitors)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication
Locally Advanced Malignant Solid NeoplasmNon-Small Cell Lung CancerEGFR-mutated non-small Cell Lung Cancer
Inactive Indication-
Originator Organization
Yuhan Corp.
Active Organization
Yonsei University College of MedicineYuhan Corp.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with YH-42946
NCT06616766
/ RecruitingPhase 1/2
A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate the Safety, Tolerability, PK and Anti-tumor Activity of YH42946 in Patients With Locally Advanced or Metastatic Solid Tumors With HER2 Aberration and EGFR Exon 20 Insertion
100 Clinical Results associated with YH-42946
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100 Translational Medicine associated with YH-42946
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100 Patents (Medical) associated with YH-42946
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100 Deals associated with YH-42946
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant Solid NeoplasmPhase 2
United States
Yuhan Corp.
02 Oct 2024
Locally Advanced Malignant Solid NeoplasmPhase 2
South Korea
Yuhan Corp.
02 Oct 2024
Non-Small Cell Lung CancerPhase 2
United States
Yuhan Corp.
02 Oct 2024
Non-Small Cell Lung CancerPhase 2
South Korea
Yuhan Corp.
02 Oct 2024
EGFR-mutated non-small Cell Lung CancerPreclinical
South Korea
Yonsei University College of Medicine
29 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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