Delving into the Latest Updates on ARB101A with Synapse

Overview

Basic Info

Drug Type

Antibody drug conjugate (ADC)

Synonyms

Target

CDH17

Mechanism

CDH17 antagonists(Cadherin-17 antagonists)

Therapeutic Areas

NeoplasmsDigestive System DisordersSkin and Musculoskeletal Diseases

Active Indication

Colonic CancerMelanoma

Inactive Indication-

Originator Organization

Arbele Corp.Startup

Active Organization

Arbele Corp.Startup

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Structure

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Author: Tai, William Chi Shing ; Leung, Wing Wa ; Wong, Yee Ni ; Yim, Aldrin Kay Yuen ; Cho, William Chi Shing ; Chan, Amanda Kit Ching ; Yu, Allen Chi Shing ; Luk, John M ; Chan, John Kwok Cheung ; Pei, Xiao Meng ; Wong, Heong Ting ; Wong, Kwong Fai ; Ng, Simon Siu Man ; Tsang, Hin Fung ; Wong, Yin Kwan Evelyn ; Wong, Sze Chuen Cesar

BACKGROUNDColorectal cancer (CRC) is the second leading cause of cancer deaths in Hong Kong. We tested the hypothesis that circulating tumor cell (CTC) analysis by ARB101 antibody could be used as a tool for CRC detection, progression, and therapy response.RESEARCH METHODSARB101 antibody was used for investigation of CDH17 expression in formalin-fixed, paraffin-embedded (FFPE) tissue sections and circulating tumor cells (CTCs) of CRC patients.RESULTSUsing ARB101, highest sensitivity was observed in 98/100 (98%) colorectal cancer tissue compared to 72/100 gastric cancer (72%) and 27/32 pancreatic cancer (84%). Immunoreactivity of CDH17 was significantly higher in distant metastatic (tumor-node-metastasis [TNM] stage IV) than non-distant metastatic (TNM stage I to III) CRC. ARB101 antibody also manifested the higher sensitivity than c-erbB2 (8%) and epidermal growth factor receptor (EGFR)-targeting antibodies (37%) with the significance (p < 0.0001). ARB101 positive CTCs were detected in 64/83 (77%) TNM stage I to IV CRC patients. Furthermore, ARB101 positive CTCs detected in TNM stage I to III CRC patients before and after surgical operation are statistically significant (p < 0.0001).CONCLUSIONSCTC detection by ARB101 antibody could serve as a potential non-invasive approach for CRC detection, progression, and monitoring of treatment response.

100 Deals associated with ARB101A

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