It is a prospective interventional randomized controlled single center trial. The goal of the trial is to evaluate the efficacy of smart soup on cognition, behavior, biomarkers and safety in Alzheimer's disease (aMCI and dementia).

Start Date01 Jun 2022

Sponsor / Collaborator

Peking Union Medical College Hospital

[+1]

100 Clinical Results associated with Smart Soup

100 Translational Medicine associated with Smart Soup

100 Patents (Medical) associated with Smart Soup

Literatures (Medical) associated with Smart Soup

28 Jul 2020·British Journal of NutritionQ3 · MEDICINE

How does a simplified recipe collection procedure in dietary assessment tools affect the food group and nutrient intake distributions of the population

Q3 · MEDICINE

Article

Author: Zhang, Liangzi ; Boshuizen, Hendriek ; Ocké, Marga

AbstractTechnology advancements have driven the use of self-administered dietary assessment methods in large-scale dietary surveys. Interviewer-assisted methods generally have a complicated recipe recording procedure enabling the adjustment from a standard recipe. In order to decide if this functionality can be omitted for self-administered dietary assessment, this study aimed to assess the extent of standard recipe modifications in the Dutch National Food Consumption Survey and measure the impact on the food group and nutrient intake distributions of the population when the modifications were disregarded. A two-scenario simulation analysis was conducted. Firstly, the individual recipe scenario omitted the full modifications to the standard recipes made by people who knew their recipes. Secondly, the modified recipe scenario omitted the modifications made by those who partially modified the standard recipe due to their limited knowledge. The weighted percentage differences for the nutrient and food group intake distributions between the scenarios and the original data set were calculated. The highest percentage of energy consumed through mixed dishes was 10 % for females aged 19–79 years. Comparing the combined scenario and the original data set, the average of the absolute percentage difference for the population mean intakes was 1·6 % across all food groups and 0·6 % for nutrients. The soup group (−6·6 %) and DHA (−2·3 %) showed the largest percentage difference. The recipe simplification caused a slight underestimation of the consumed amount of both foods (−0·2 %) and nutrients (−0·4 %). These results are promising for developing self-administered 24-hour recalls or food diary applications without complex recipe function.

01 Dec 2014·Acta Crystallographica Section D Biological Crystallography

High-synconformation of uridine and asymmetry of the hexameric molecule revealed in the high-resolution structures ofShewanella oneidensisMR-1 uridine phosphorylase in the free form and in complex with uridine

Article

Author: Kovalchuk, Mikhail V ; Mordkovich, Nadezhda N ; Manuvera, Valentin A ; Mikhailov, Sergey N ; Veiko, Vladimir P ; Alekseev, Cyril S ; Safonova, Tatyana N ; Polyakov, Konstantin M ; Popov, Vladimir O

Uridine phosphorylase (UP; EC 2.4.2.3), a key enzyme in the pyrimidine-salvage pathway, catalyzes the reversible phosphorolysis of uridine to uracil and ribose 1-phosphate. Expression of UP fromShewanella oneidensisMR-1 (SoUP) was performed inEscherichia coli. The high-resolution X-ray structure of SoUP was solved in the free form and in complex with uridine. A crystal of SoUP in the free form was grown under microgravity and diffracted to ultrahigh resolution. Both forms of SoUP contained sulfate instead of phosphate in the active site owing to the presence of ammonium sulfate in the crystallization solution. The latter can be considered as a good mimic of phosphate. In the complex, uridine adopts a high-synconformation with a nearly planar ribose ring and is present only in one subunit of the hexamer. A comparison of the structures of SoUP in the free form and in complex with the natural substrate uridine showed that the subunits of the hexamer are not identical, with the active sites having either an open or a closed conformation. In the monomers with the closed conformation, the active sites in which uridine is absent contain a glycerol molecule mimicking the ribose moiety of uridine.

01 Jan 2014·International journal of clinical and experimental medicine

Combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of elderly women.

Article

Author: Xu, Rong-Mei ; Zhao, Xin-Ping ; Song, Qing-Hua ; Guo, Yan-Hua ; Wang, Yi ; Shen, Guo-Qing ; Zhang, Quan-Hai ; Ma, Ming

OBJECTIVETo observe the combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of women of advanced years.DESIGN120 elderly women lacking daily exercise were chosen as the study subjects. By using the table of random numbers, they were then divided into the control group and the experiment group, consisting of 60 each. The control group practiced Taiji boxing for 45 minutes twice a day. The experiment group did the same, and, in addition, took astragalus soup after each boxing. Indexes related to physical immunity of the two groups were observed and compared when they were first chosen, when the alternative treatment was applied three, six and twelve months later, respectively.RESULTSThe two groups demonstrated no significant differences in general data and research indexes when chosen (P > 0.05). Three months after the two groups were chosen and treated differently, the control group demonstrated no significant improvement while most indexes of the experiment group improved considerably (P > 0.05). After six months, the related indexes of both groups improved substantially (P < 0.05) and the improvement with the experiment was even clearer (P < 0.05). Twelve months later, the improvement with the experiment group was more noticeable (P < 0.01 or P < 0.05).CONCLUSIONSIn a relatively short period of three months, Taiji boxing produces no noticeable effect on the improvement of immunity in elderly women. However, when they resume the exercise for another three months and longer, Taiji boxing has a noticeable advantage and the effect is the most favorable when it is combined with astragalus soup.

100 Deals associated with Smart Soup

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Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Phase 2	CN	Peking Union Medical College Hospital	01 Jun 2022
Mild cognitive disorder	Phase 2	CN	Peking Union Medical College Hospital	01 Jun 2022

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