Delving into the Latest Updates on Glycine/lysine acetylsalicylate inhalation(Vectura) with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Glycine/lysine acetylsalicylate, LASAG, Lysine acetylsalicylate glycine

+ [4]

Target-

Mechanism

Virus replication inhibitors

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication

Influenza B virus infectionInfluenza, Human

Inactive Indication-

Originator Organization

Vectura Group Ltd.

Active Organization

Ventaleon GmbH

Vectura Group Ltd.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure

Molecular FormulaC2H5NO2

InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N

CAS Registry56-40-6

View All Structures (2)

Background:This case report highlights a rare occurrence of aspirin overdose presenting only as severe coagulopathy.Case presentation:An 85-year-old woman was admitted to the hospital with multiple lumbar vertebral compression fractures causing severe back pain. The patient had self-medicated with excessive consumption of Bufferin A containing 330 mg of aspirin. On arrival, she showed no typical symptoms of salicylate toxicity, such as nausea, vomiting, hyperventilation, tinnitus, or hearing loss. However, blood work revealed a significant decrease in vitamin K–dependent coagulation factors leading to coagulopathy. The administration of 20-mg menatetrenone (vitamin K) resulted in rapid improvement in coagulation abnormalities. The patient's blood salicylate level was later determined to be 42.7 mg/dL.Discussion:Acute salicylate poisoning is known to cause coagulopathy because of the inhibition of vitamin K–dependent coagulation factors. However, this case is unique because it demonstrates coagulopathy as the sole manifestation of aspirin toxicity without any other symptoms.Conclusions:This case highlights the importance of considering the possibility of aspirin toxicity in patients with coagulopathy, especially those who are regularly consuming aspirin.

01 May 2024·Advanced Science

Aspirin‐Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis

Article

Author: Yu, Xiaofei ; Wu, Zhen ; Zhang, Xumin ; Yu, Wei ; Chen, Chunyu ; Xie, Liangguo ; Li, Chaoqun ; Wang, Chao ; Lin, Jinzhong ; Wang, Changchun ; Zhou, Dejian ; Lu, Ping ; Chen, Xiaojian ; Liu, Chen-Ying ; Zhou, Qiang ; Ding, Chen

AbstractAspirin, also named acetylsalicylate, can directly acetylate the side‐chain of lysine in protein, which leads to the possibility of unexplained drug effects. Here, the study used isotopic‐labeling aspirin‐d3 with mass spectrometry analysis to discover that aspirin directly acetylates 10 HDACs proteins, including SIRT1, the most studied NAD+‐dependent deacetylase. SIRT1 is also acetylated by aspirin in vitro. It is also identified that aspirin directly acetylates lysine 408 of SIRT1, which abolishes SIRT1 deacetylation activity by impairing the substrates binding affinity. Interestingly, the lysine 408 of SIRT1 can be acetylated by CBP acetyltransferase in cells without aspirin supplement. Aspirin can inhibit SIRT1 to increase the levels of acetylated p53 and promote p53‐dependent apoptosis. Moreover, the knock‐in mice of the acetylation‐mimic mutant of SIRT1 show the decreased production of pro‐inflammatory cytokines and maintain intestinal immune homeostasis. The study indicates the importance of the acetylated internal functional site of SIRT1 in maintaining intestinal immune homeostasis.

01 Apr 2024·International Journal of Biological Macromolecules

Hyaluronic acid from bluefin tuna by-product: Structural analysis and pharmacological activities

Article

Author: Chaubet, Frédéric ; Boisson-Vidal, Catherine ; Elhiss, Sawsen ; Kraiem, Jamil ; Chahed, Latifa ; Maaroufi, Raoui Mounir ; Majdoub, Hatem ; Laschet, Jamila ; Le Cerf, Didier ; Ben Mansour, Mohamed ; Hamdi, Assia ; Bouchemal, Nadia

The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((¹D¹H) and 2D (¹H COSY, ¹H/¹³C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins.

100 Deals associated with Glycine/lysine acetylsalicylate inhalation(Vectura)

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