Last update 16 May 2025

AE-101

Overview

Basic Info

Drug Type
Cell therapy
Synonyms
AE 101, ARVN-901, ARVN901
+ [2]
Target
ROCK
Action
inhibitors
Mechanism
ROCK inhibitors(Rho-associated kinases inhibitors)
Therapeutic Areas
Cardiovascular DiseasesCongenital DisordersEye Diseases+ [1]
Active Indication
Bullous keratopathyEndothelial dysfunctionCorneal endotheliolitis+ [1]
Inactive Indication-
Originator Organization
ActualEyes, Inc.ActualEyes, Inc.
Active Organization
ActualEyes, Inc.ActualEyes, Inc.Arctic Vision (Shanghai) Biotechnology Co., Ltd.Arctic Vision (Shanghai) Biotechnology Co., Ltd.
D. Western Therapeutics Institute, Inc.D. Western Therapeutics Institute, Inc.
Inactive Organization-
License Organization
ActualEyes, Inc.ActualEyes, Inc.Changzhou Jimu Biotechnology Co., Ltd.D. Western Therapeutics Institute, Inc.D. Western Therapeutics Institute, Inc.
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

100 Clinical Results associated with AE-101
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100 Translational Medicine associated with AE-101
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100 Patents (Medical) associated with AE-101
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100 Deals associated with AE-101
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bullous keratopathyPhase 2
Japan
D. Western Therapeutics Institute, Inc.D. Western Therapeutics Institute, Inc.
11 Jun 2024
Bullous keratopathyPhase 2
Japan
ActualEyes, Inc.ActualEyes, Inc.
11 Jun 2024
Endothelial dysfunctionPreclinical
China
Arctic Vision (Shanghai) Biotechnology Co., Ltd.Arctic Vision (Shanghai) Biotechnology Co., Ltd.
01 May 2025
Corneal endotheliolitisPreclinical
Japan
ActualEyes, Inc.ActualEyes, Inc.
30 Jan 2022
Fuchs' Endothelial DystrophyPreclinical
Japan
ActualEyes, Inc.ActualEyes, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Clinical Trial

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Approval

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Regulation

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