Last update 14 Feb 2026

ADV/HSV-tk (The Methodist Hospital Research Institute)

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms-
Target
TK
Action
stimulants
Mechanism
thymidine kinase stimulants(Thymidine kinase stimulants)
Therapeutic Areas
NeoplasmsNervous System DiseasesOther Diseases
Active Indication
Glioblastoma Multiforme
Inactive Indication-
Originator Organization
The Methodist Hospital Research Institute
Active Organization
The Methodist Hospital Research Institute
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with ADV/HSV-tk (The Methodist Hospital Research Institute)
NCT03541928
/ Unknown statusPhase 2IIT
Phase II Study Evaluating HSV-tk + Valacyclovir Gene Therapy in Combination With Androgen Deprivation Therapy, Brachytherapy, External Beam Radiotherapy, and Prostatectomy for High-Risk Prostate Cancer
NCT03603405
/ RecruitingPhase 1/2IIT
Phase I-II Study Evaluating HSV-tK + VALACYCLOVIR GENE THERAPY Combination with Radiotherapy and Chemotherapy for Newly Diagnosed Anaplastic Astrocytoma and Glioblastoma Multiforme.
NCT03596086
/ RecruitingPhase 1/2IIT
Phase I-II Study Evaluating HSV-tk + Valacyclovir Gene Therapy Combination with Radiotherapy and Chemotherapy for Recurrent Glioblastoma Multiforme
100 Clinical Results associated with ADV/HSV-tk (The Methodist Hospital Research Institute)
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100 Translational Medicine associated with ADV/HSV-tk (The Methodist Hospital Research Institute)
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100 Patents (Medical) associated with ADV/HSV-tk (The Methodist Hospital Research Institute)
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100 Deals associated with ADV/HSV-tk (The Methodist Hospital Research Institute)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
United States
The Methodist Hospital Research Institute
28 Feb 2018
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Clinical Result

Indication
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Clinical Trial

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Approval

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Regulation

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