Last update 20 Mar 2025

CBPD-268

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
Target
CREBBP x EP300 x EP300/CBP
Action
inhibitors
Mechanism
CREBBP inhibitors(cAMP-response element binding protein inhibitors), EP300 inhibitors(Histone acetyltransferase p300 inhibitors), EP300/CBP inhibitors(CREBBP/EP300 inhibitors)
Therapeutic Areas
NeoplasmsUrogenital Diseases
Active Indication
Prostatic CancerCastration-Resistant Prostatic Cancer
Inactive Indication-
Originator Organization
University of Michigan College of EngineeringUniversity of Michigan College of Engineering
Active Organization
University of MichiganUniversity of MichiganUniversity of Michigan College of EngineeringUniversity of Michigan College of Engineering
Inactive Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC44H47F2N9O5
InChIKeyNORRDWRSNUOCBV-XCIZWWPASA-N
CAS Registry2832961-58-5

Related

100 Clinical Results associated with CBPD-268
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100 Translational Medicine associated with CBPD-268
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100 Patents (Medical) associated with CBPD-268
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1
Literatures (Medical) associated with CBPD-268
11 Apr 2024Journal of Medicinal ChemistryQ1 · MEDICINE
Discovery of CBPD-268 as an Exceptionally Potent and Orally Efficacious CBP/p300 PROTAC Degrader Capable of Achieving Tumor Regression
Q1 · MEDICINE
100 Deals associated with CBPD-268
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Prostatic CancerPreclinical
United States
University of Michigan College of EngineeringUniversity of Michigan College of Engineering
25 Mar 2024
Castration-Resistant Prostatic CancerPreclinical
United States
University of MichiganUniversity of Michigan
22 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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