Last update 17 Apr 2025

LY-3849891

Overview

Basic Info

Drug Type
siRNA
Synonyms
PNPLA3 siRNA, LY 3849891, LY3849891
Target
PNPLA3
Action
inhibitors
Mechanism
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 inhibitors
Therapeutic Areas
Digestive System Disorders
Active Indication
Nonalcoholic Steatohepatitis
Inactive Indication-
Originator Organization
Dicerna Pharmaceuticals, Inc.Dicerna Pharmaceuticals, Inc.
Active Organization
Eli Lilly & Co.Eli Lilly & Co.
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with LY-3849891
NCT05395481
/ RecruitingPhase 1
A Single-Ascending and Repeated Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3849891 in Participants with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Who Have the PNPLA3 I148M Genotype
100 Clinical Results associated with LY-3849891
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100 Translational Medicine associated with LY-3849891
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100 Patents (Medical) associated with LY-3849891
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100 Deals associated with LY-3849891
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonalcoholic SteatohepatitisPhase 1
United States
Eli Lilly & Co.Eli Lilly & Co.
08 Jun 2022
Nonalcoholic SteatohepatitisPhase 1
Japan
Eli Lilly & Co.Eli Lilly & Co.
08 Jun 2022
Nonalcoholic SteatohepatitisPhase 1
Puerto Rico
Eli Lilly & Co.Eli Lilly & Co.
08 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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