Covalent organic frameworks (COFs) are a novel materials platform that combines covalent connectivity, structural regularity, and molecularly precise porosity.However, COFs usually form insoluble aggregates, which limits their wide application in separation membranes.Here, we adopted "reaction-separation-assembly" strategy to produce continuous and uniform COFs membranes with controllable thickness.Our exptl. data showed that the strategy can manipulate colloidal COFs suspensions to create tailored selective layer.The obtained membranes exhibited high pure water flux of 150 L m ^-2 h^-1 bar^-1, good salt/dyes separation factor and superior mol. sieving ability (> 90 % for active pharmaceutical ingredients, >97 % for dyes mols.), which is substantially higher than that of com. NF1.In addition, the prepared composite membranes showed superior stability, especially under harsh conditions such as strong acids (4 mol L^-1 HCl) and strong bases (2 mol L^-1 NaOH).Overall, this work provides a promising approach for highly permeable and stable COFs membranes, and facilitates rapid recycling of small organic mols. such as active pharmaceutical ingredients and dyes.

01 Dec 2024·Fitoterapia

Phytochemical and pharmacological investigation of the non-volatile compounds of Lepidium cartilagineum (J. C. Mayer) Thell. and determination of the essential oil composition of its flowers and fruits

Article

Author: Vasas, Andrea ; Barta, Anita ; Kincses, Annamária ; Veres, Katalin ; Hohmann, Judit ; Sápi, Tamara ; Kúsz, Norbert ; Cui, Zuhao ; Dávid, Csilla Zsuzsanna ; Bakacsy, László

Eighteen compounds, among them phenylpropanoids (1-2), neolignans (3-9), a megastigmane (10), a phenyl glucoside (11), flavonoids (12-14), and N-containing compounds (15-18) were isolated from the methanolic extract of the whole plant of L. cartilagineum. The structures of the compounds were determined by NMR and MS measurements. The composition of the essential oils prepared from the flowers and fruits of L. cartilagineum was investigated using GC and GC-MS measurements. The essential oils were rich in aliphatic aldehydes and hydrocarbons, but low in sulfur-containing compounds, e.g., isothiocyanates. The extracts prepared from the aerial parts and roots of the plant, the essential oil, and the isolated compounds (1-9) were tested for antiproliferative activity against COLO 205 and COLO 320 cell lines and antibacterial activity on Lactobacillus rhamnosus. Dehydrodiconiferyl alcohol γ'-methyl ether (5) possessed marked antiproliferative activity against both human tumor cell lines. Neither the extracts nor the compounds affected the growth of the bacteria and did not influence the biofilm formation of L. rhamnosus. Based on the results, it can be concluded that L. cartilagineum is non-toxic to the human gut microbiome forming L. rhamnosus.

01 Dec 2024·Microchemical Journal

Developing an effective approach based on microwave distillation and extraction using deep eutectic solvents for multiple target analytes prepared from Eleutherococcus senticosus fruits

Author: Meng, Yue ; Liu, Tingting ; Yuan, Cheng ; Yang, Ying ; Zhang, Xinyi ; Sui, Xiaoyu ; Zhang, Honglian ; Pan, Xu

Deep eutectic solvents (DES) have emerged as an environmentally-friendly alternative for extracting active ingredients from botanical materials.The combination of the microwave extraction method and DES can enhance mass transfer, and DES are an excellent alternative solvent for microwave solid-liquid extraction, having a low volatility and thermal expansion coefficientIn the present study, we used the microwave-assisted extraction/distillation technique to help the upgraded DES extract essential oil fractions and unique active ingredients (different in polarity) from Eleutherococcus senticosus fruits at the same time.After single-factor trials and a Box-Behnken design (BBD) and experiments, the total yield of the three target constituents, eleutheroside B, eleutheroside E, and isofraxidin, was 30.11 ± 0.16 mg/g, that of anthocyanins was 6.29 ± 0.11 mg/g, and that of essential oil was 2.00 ± 0.13 mg/g.Compared with other methods, the proposed method ensures that DES are compatible with microwave processes and that several types of components can be extracted

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Indication	Highest Phase	Country/Location	Organization	Date
Osteoporosis	Preclinical	China	The 1St Affiliated Hosp of Guangdong Pharm University	11 Apr 2024

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