[Translation] A randomized double-blind, single-dummy, multicenter clinical trial to evaluate the efficacy and safety of Shenwei Ningyu tablets in the treatment of depression (Qi and Yin deficiency syndrome) with placebo as parallel control

进一步评价参味宁郁片治疗抑郁症（气阴两虚证）的有效性及安全性。

[Translation]

To further evaluate the efficacy and safety of Shenwei Ningyu Tablets in the treatment of depression (Qi and Yin deficiency syndrome).

Start Date25 May 2018

Sponsor / Collaborator

Guangdong Siji Pharmaceutical Co., Ltd.

[+1]

100 Clinical Results associated with Shenyu Ningshen Tablets

100 Translational Medicine associated with Shenyu Ningshen Tablets

100 Patents (Medical) associated with Shenyu Ningshen Tablets

Literatures (Medical) associated with Shenyu Ningshen Tablets

01 Apr 2024·Heliyon

Shenyu ningshen tablet reduced neuronal damage in the hippocampus of chronic restraint stress model rat by inhibiting A1-reactive astrocytes

Article

Author: Yao, Rongmei ; Zhou, Lirun ; Pang, Bo ; Zeng, Meihua ; Cao, Shan ; Wang, Yaxin ; Li, Shuran ; Chen, Mengping ; Xu, Yingli ; Cui, Xiaolan ; Guo, Shanshan

ContextShenyu Ningshen (SYNS) tablet is the first pure Chinese medicinal small compound preparation approved for clinical trials for the treatment of depression in China. Clinical experiments confirmed that the formulation had a significant Improvement effect against depression due to the deficiency of both qi and yin. It has been shown to exhibit noticeable anti-inflammatory effect in an animal model of depression. Our previous study showed that SYNS could effectively inhibit the inflammatory response in a depression model.Aim of the studyThe purpose of this study was to investigate the protective effects of SYNS on neurons and explore whether the underlying mechanism was associated with A1s.Materials and methodsThe depression model of solitary raising-chronic restraint stress (CRS) rats was established; body weight examination, sugar water preference test, open field test, and histological analysis were performed to preliminarily verify the efficacy of the formulation. Subsequently, neuronal nucleus (NeuN) and synaptic-associated proteins (MAP2 and PSD95) were labeled, and the protective effect of SYNS on hippocampal neurons was observed based on the fluorescence intensity of the above indicators. Western blotting, histological examination, and immunofluorescence were used to evaluate the inhibitory effects of SYNS on neuroinflammation and activation of A1s in CRS depression model.ResultsSYNS improved behavioral indicators such as weight loss, pleasure loss, and reduced exercise volume in CRS rat model. SYNS restored the CRS-induced histopathological changes in the hippocampus. SYNS showed a certain degree of protective effect on synapses. Further, SYNS inhibited the activation of A1s by inhibiting neuroinflammatory factors in the hippocampus.ConclusionOur results showed that SYNS had a certain degree of neuroprotective effect, which might be related to its inhibition of the inflammatory response and A1s.

100 Deals associated with Shenyu Ningshen Tablets

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Indication	Country/Location	Organization	Date
Depressive Disorder	CN	Guangdong Siji Pharmaceutical Co., Ltd.	08 Jun 2023

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Depressive Disorder	Preclinical	CN	Guangdong Laida Pharmaceutical Co., Ltd.	25 May 2018

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