ADRA2B agonists(Alpha-2b adrenergic receptor agonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), α2A-AR agonists(Alpha-2a adrenergic receptor agonists)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Boehringer Ingelheim GmbH

Active Organization-

Inactive Organization

Boehringer Ingelheim Pharmaceuticals, Inc.

Drug Highest PhaseWithdrawn

First Approval Date

US (03 Sep 1974)

Regulation-

Structure

Molecular FormulaC14H11ClN2O4S

InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N

CAS Registry77-36-1

View All Structures (2)

Clinical Trials associated with Chlorthalidone/Clonidine Hydrochloride

NCT01191450 / Unknown statusPhase 3

A Study to Evaluate the Safety and Efficacy of Chlorthalidone in Combination With Amiloride as a Treatment for Elderly Patients With Arterial Hypertension

The purpose of this study is to assess the efficacy and safety of Chlorthalidone 25 mg + amiloride hydrochloride 5 mg association in the treatment of elderly patients with arterial hypertension.

Start Date01 Aug 2011

Sponsor / Collaborator

Eurofarma Laboratórios SA

100 Clinical Results associated with Chlorthalidone/Clonidine Hydrochloride

100 Translational Medicine associated with Chlorthalidone/Clonidine Hydrochloride

100 Patents (Medical) associated with Chlorthalidone/Clonidine Hydrochloride

Literatures (Medical) associated with Chlorthalidone/Clonidine Hydrochloride

01 Nov 1980·Clinical pharmacology and therapeuticsQ2 · MEDICINE

Clonidine-chlorthalidone combination once and twice daily in essential hypertension

Q2 · MEDICINE

Article

Author: Jerome R Ryan ; Adesh K Jain ; Robert J Noveck ; F Gilbert McMahon

The antihypertensive effects of a clonidine-chlorthalidone combination (Combipres) as a single daily dose at bedtime and the same amount in twice-daily doses were compared in an open-label, crossover study in 14 patients. An analysis of the blood pressure and pulse data in nine patients who completed the study revealed no statistically significant differences between the two regimens, and no difference in the incidence of side effects was noted.

01 Apr 1980·Journal of clinical pharmacologyQ3 · MEDICINE

Blood Pressure Response to a Single Daily Dose of a Clonidine—Chlorthalidone Combination

Q3 · MEDICINE

Article

Author: J. Caulie Gunnells ; Steven H. Grossman

A single evening dose of a clonidine-chlorthalidone combination (Combipres) was compared with the usual twice-daily schedule in 11 patients with essential hypertension. No significant difference was found between the blood pressures recorded on the two regimens or between morning and afternoon pressures on the once-daily schedule. Only one patient did not maintain adequate blood pressure control. We suggest that some patients with essential hypertension can be adequately treated with a single daily dose of a combination of clonidine and chlorthalidone.

12 Sep 1975·The Medical letter on drugs and therapeuticsQ4 · MEDICINE

Combipres for hypertension.

Q4 · MEDICINE

Article

100 Deals associated with Chlorthalidone/Clonidine Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
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