[Translation] A Phase Ib clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics, and pharmacodynamic characteristics of multiple oral doses of PA3670 tablets in Chinese patients with chronic hepatitis B
主要目的:
评价多次口服PA3670片在中国慢性乙型肝炎患者中的安全性和耐受性。
评价多次口服PA3670片在中国慢性乙型肝炎患者中的药效特征。
次要目的:
评估多次口服PA3670片在中国慢性乙型肝炎患者中的药代动力学特征。
初步探索PA3670片多次口服给药治疗慢性乙型肝炎的Ⅱ期临床推荐剂量及频率。
[Translation] Primary objective:
To evaluate the safety and tolerability of multiple oral administration of PA3670 tablets in Chinese patients with chronic hepatitis B.
To evaluate the pharmacodynamic characteristics of multiple oral administration of PA3670 tablets in Chinese patients with chronic hepatitis B.
Secondary objective:
To evaluate the pharmacokinetic characteristics of multiple oral administration of PA3670 tablets in Chinese patients with chronic hepatitis B.
To preliminarily explore the recommended dose and frequency of multiple oral administration of PA3670 tablets for the treatment of chronic hepatitis B in Phase II clinical trials.