Last update 29 Nov 2025

Zavacorilant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CORT 125329, CORT125329
Target
GR
Action
antagonists
Mechanism
GR antagonists(Glucocorticoid receptor antagonists)
Therapeutic Areas-
Active Indication-
Inactive Indication-
Originator Organization
Corcept Therapeutics, Inc.Corcept Therapeutics, Inc.
Active Organization-
Inactive Organization
Corcept Therapeutics, Inc.Corcept Therapeutics, Inc.
License Organization-
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H26FN7O3S2
InChIKeyDUHWKWNCLIALLV-BVZFJXPGSA-N
CAS Registry1781245-13-3

Related

3
Clinical Trials associated with Zavacorilant
ISRCTN14072771
/ RecruitingPhase 1
A Phase I pharmacokinetic assessment of zavacorilant softgel capsule formulation, including dose proportionality and food effect in healthy subjects
ISRCTN20653849
/ RecruitingPhase 1
An open label, single-dose, single-period study designed to assess the mass balance recovery, metabolite profile and metabolite identification of [14C]-CORT125329 in healthy male subjects
NCT04672512
/ CompletedPhase 1
A Phase 1 Adaptive Dose, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Administered CORT125329 in Healthy Subjects, With an Optional Pharmacological Effects Cohort
100 Clinical Results associated with Zavacorilant
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100 Translational Medicine associated with Zavacorilant
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100 Patents (Medical) associated with Zavacorilant
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100 Deals associated with Zavacorilant
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R&D Status

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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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