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Last update 23 Aug 2025
SC-0011
Last update 23 Aug 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms SC 0011, SC-0011, SC0011 |
Target |
Action antagonists |
Mechanism FGFRs antagonists(Fibroblast growth factor receptors antagonists) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Related
2
Clinical Trials associated with SC-0011CTR20233256
一项评价SC0011联合阿帕替尼在晚期胃癌/胃食管结合部腺癌受试者中的安全性、耐受性、有效性的多中心、开放性的Ib期临床研究
[Translation] A multicenter, open-label Phase Ib clinical study to evaluate the safety, tolerability, and efficacy of SC0011 combined with apatinib in subjects with advanced gastric cancer/gastroesophageal junction adenocarcinoma
CTR20210215
一项多中心、开放、单臂、非随机的I 期临床试验：评估泛FGFR 抑制剂SC0011 片在晚期恶性实体瘤患者的安全性、耐受性、药代动力学及药效动力学特征，并初步探索SC0011 片的抗肿瘤活性
[Translation] A multicenter, open, single-arm, non-randomized Phase I clinical trial: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of the pan-FGFR inhibitor SC0011 tablets in patients with advanced malignant solid tumors, and to preliminarily explore the anti-tumor activity of SC0011 tablets
100 Clinical Results associated with SC-0011
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100 Translational Medicine associated with SC-0011
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100 Patents (Medical) associated with SC-0011
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1
Literatures (Medical) associated with SC-001101 Jan 1963Biochimica et biophysica acta
Aromatization in vivo of 3 β, 17β-bisacetoxy-17α-ethynyl-19-nor-androst-4-ene (SC-II 800)
Article
Author: Besch, P. K. ; Vorys, N. ; Barry, R. D. ; Watson, D. J.
SC-11,800 (60 mg.) was administered orally to women, and urine subsequently collected was analyzed.Pre-, during, and post-drug urinary levels of etiocholanolone, androsterone, dehydroepiandrosterone, 11-oxoetiocholanolone, 11-hydroxyetiocholanolone, 11-oxoandrosterone, and 11-hydroxyandrosterone remained the same.Significant urinary estrogen alterations of estrone, estradiol, and estriol were observed.A different phenolic metabolite appeared only in urine collected during the ingestion period.This was identified as 17α-ethynylestradiol, which appeared to the extent of 58 γ/24-hr. urine.
100 Deals associated with SC-0011
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced gastric carcinoma | Phase 1 | China | 08 Jan 2024 | |
| Gastroesophageal junction adenocarcinoma | Phase 1 | China | 08 Jan 2024 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 04 Mar 2021 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | IND Approval | - | 21 Dec 2023 | |
| metastatic non-small cell lung cancer | IND Approval | - | 21 Dec 2023 |
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