Author: Yamada, Takatoshi ; Ishizaki, Masayuki ; Inagaki, Naoki ; Ohashi, Tetsuo ; Musoh, Keiichi ; Nagai, Hiroichi ; Takahashi, Yoshimasa ; Tanaka, Hiroyuki

The effects of 4-[4-[5,5,6,6,6-pentafluoro-1-(4-fluorobenzene-sulfonamido)hexyl]phenyl]butyric acid (RS-601), a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, on bronchial asthmatic responses in guinea pigs were examined. The effects were compared with those of pranlukast (LTD4 receptor antagonist) and S-1452 (TxA2 receptor antagonist). RS-601 inhibited the increase in airway resistance caused by LTD4 and TxA2 mimetic compound, U-46619, but not by histamine. RS-601 and pranlukast but not S-1452 inhibited an antigen-induced late asthmatic response. In addition, RS-601 inhibited an antigen-induced airway hyperresponsiveness (AHR), whereas pranlukast and S-1452 had no effect on the AHR. The antigen-induced increase in inflammatory cells in airway was not affected by all examined agents. Furthermore, bacterial lipopolysaccharide-induced AHR in guinea pigs was clearly suppressed by RS-601 but not by pranlukast and S-1452. The increase in airway inflammatory cells caused by lipopolysaccharide was not affected by all three drugs. These findings indicate that RS-601 has a potent antiasthmatic efficacy, especially on AHR, but does not affect accumulation of eosinophils in the airways.

01 Jan 2001·Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

The Ultrafast Energy Transfer Process in Purple Bacteria Photosynthetic Reaction Center.

Article

Author: Zou, Yong-Long ; Qian, Shi-Xiong ; Yang, Yi ; Xu, Chun-He ; Guo, Li-Jun ; Ma, Guo-Hong ; Liu, Yuan

The ultrafast energy transfer process, which takes place in femtosecond time range, in bacterial photosynthetic reaction center RS601 was investigated using femtosecond pump-probe technique with selective excitation. Upon 755 nmexcitation, the excited state of bacteriopheophytin H decayed to bacteriochlorophyll B with a time constant of about 130 fs, while the excited state of B transported the energy to its energy acceptor, the dimeric bacteriochlorophyll P, in about 240 fs with the 800 nm excitation. The internal conversion process between the upper and lower exciton levels of special pair P might exist upon the excitation of 850 nm pulses. In addition, from the results obtained in our experiments, the charge separation and electron transfer from P to the acceptor H was also observed via the real intermediate B within a few picoseconds.

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Indication	Highest Phase	Country/Location	Organization	Date
Asthma	Discovery	JP	Abbott Laboratories (Philippines), Inc.	-

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