An Ascending Multiple-Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315 Administered Orally to Healthy Young Adult and Elderly Subjects

Primary: To assess the safety and tolerability of ascending multiple oral doses of SAM-315, an investigational drug, in healthy young adult and elderly subjects.
Secondary: To assess the Pharmacokinetic and Pharmacodynamic profiles of multiple oral doses of SAM-315 in healthy young adult and elderly subjects.

Start Date01 Jun 2007

Sponsor / Collaborator

Wyeth AB

NCT00480467 / CompletedPhase 1

Ascending Single Dose Study of the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of SAM-315 Administered Orally to Healthy Japanese Male Subjects

To assess the safety and tolerability of ascending single oral doses of SAM-315, an investigational drug, in healthy Japanese male subjects.To obtain preliminary pharmacokinetic (PK) and pharmacodynamic (PD) profiles of SAM-315 in healthy Japanese male subjects.

Start Date01 Sep 2006

Sponsor / Collaborator

Wyeth AB

NCT00479440 / CompletedPhase 1

Ascending Single Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315 Administered Orally to Healthy Adult Subjects

To assess the safety and tolerability of ascending single oral doses of SAM-315, an investigational drug, in healthy adult subjects. To obtain a preliminary pharmacokinetic (PK) and pharmacodynamic (PD) profiles of SAM-315 in healthy subjects and to evaluate the effect of a high-fat meal on the PK of SAM-315, an investigation drug, administered to healthy adult subjects.

Start Date01 Aug 2006

Sponsor / Collaborator

Wyeth AB

100 Clinical Results associated with SAM-315

100 Translational Medicine associated with SAM-315

100 Patents (Medical) associated with SAM-315

Literatures (Medical) associated with SAM-315

11 Nov 2010·Journal of medicinal chemistryQ1 · MEDICINE

5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists

Q1 · MEDICINE

Article

Author: Yan, Yinfa ; Huselton, Christine ; Comery, Thomas A. ; Liu, Kevin G. ; Schechter, Lee E. ; Lo, Jennifer R. ; Zhang, Jean Y. ; Zhang, Mei-Yi ; Smith, Deborah L. ; Kowal, Dianne M. ; Hughes, Zoe A. ; Bernotas, Ronald C. ; Robichaud, Albert J. ; Zhang, Guo Ming

As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT(6) antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.

100 Deals associated with SAM-315

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Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Phase 1	-	Wyeth AB	01 Aug 2006

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